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Target Snapshot

CHEMBL613533 Target Snapshot

XF498 · CELL-LINE · Homo sapiens

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11,830Compounds
77Assays
3Approved Drugs
292.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats XF498 as ChEMBL target CHEMBL613533. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
XF498
CELL-LINE · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL613533
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether XF498 still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameXF498
Target TypeCELL-LINE
OrganismHomo sapiens
ChEMBL ↗

Next Actions

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelXF498
UniProt AccessionN/A

XF498

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as XF498.

Review nameXF498
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

3
Approved
2
Phase III
1
Phase II
Assay Mix

Activity Type Distribution

IC50284.0
EC508.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL259989 8.4 IC50 4.0 Preclinical
CHEMBL53463 8.05 IC50 9.0 Approved
CHEMBL4789549 7.92 IC50 12.0 Preclinical
CHEMBL229678 7.89 IC50 13.0 Preclinical
CHEMBL229726 7.89 IC50 13.0 Preclinical
CHEMBL261342 7.85 IC50 14.0 Preclinical
CHEMBL261876 7.77 IC50 17.0 Preclinical
CHEMBL261330 7.75 IC50 18.0 Preclinical
CHEMBL260223 7.72 IC50 19.0 Preclinical
CHEMBL261294 7.72 IC50 19.0 Preclinical
Distribution

pChEMBL Value Distribution

29
5.0
23
5.5
19
6.0
13
6.5
15
7.0
11
7.5
2
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

DOXORUBICIN
CHEMBL53463
Approved 1974
Properties Compare Identifier
Assay Landscape

Assay Landscape

78
Total Assays
138
Tested Compounds
2
Assay Types
Functional — 77 assays, 138 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 77 138 5.9
ADME — 1 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 1 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine