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Target Snapshot

CHEMBL613606 Target Snapshot

Aorta · TISSUE · Rattus norvegicus

1,388Compounds
486Assays
19Approved Drugs
1,223.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Aorta as ChEMBL target CHEMBL613606. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Aorta
TISSUE · Rattus norvegicus
As of 2026-09-13
ChEMBL target ID
CHEMBL613606
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Aorta still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelAorta
UniProt AccessionN/A

Aorta

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Aorta.

Review nameAorta
OrganismRattus norvegicus
Clinical Profile

Clinical Phase Distribution

19
Approved
3
Phase III
7
Phase II
1
Phase I
Assay Mix

Activity Type Distribution

IC50400.0
EC50823.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL121402 10.38 IC50 0.04169 Preclinical
CHEMBL4065900 9.3 EC50 0.5012 Preclinical
CHEMBL5414487 9.18 EC50 0.6607 Preclinical
CHEMBL5396036 9.13 EC50 0.7413 Preclinical
CHEMBL1084337 9.05 EC50 0.9 Preclinical
CHEMBL3823393 9.03 EC50 0.9333 Preclinical
CHEMBL5401911 9.02 EC50 0.955 Preclinical
CHEMBL3823573 9.01 EC50 0.9772 Preclinical
CHEMBL3823574 8.99 EC50 1.023 Preclinical
CHEMBL3824195 8.99 EC50 1.023 Preclinical
Distribution

pChEMBL Value Distribution

164
5.0
127
5.5
78
6.0
80
6.5
50
7.0
27
7.5
22
8.0
15
8.5
7
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

RIOCIGUAT
CHEMBL2107834
Approved 2013
SILODOSIN
CHEMBL24778
Approved 2008
PINACIDIL ANHYDROUS
CHEMBL1159
Approved 1989
MILRINONE
CHEMBL189
Approved 1987
NIFEDIPINE
CHEMBL193
Approved 1981
NITROGLYCERIN
CHEMBL730
Approved 1981
VERAPAMIL
CHEMBL6966
Approved 1981
ACETYLCHOLINE
CHEMBL667
Approved 1973
CARBACHOL
CHEMBL14
Approved 1972
Assay Landscape

Assay Landscape

486
Total Assays
712
Tested Compounds
3
Assay Types
Functional — 455 assays, 712 compounds
BAO Format Assays Compounds Avg pChEMBL
tissue-based format 433 696 5.6
assay format 20 16 8.3
organism-based format 2 0
ADME — 25 assays, 3 compounds
BAO Format Assays Compounds Avg pChEMBL
organism-based format 15 0
tissue-based format 10 3 6.9
Toxicity — 6 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
tissue-based format 4 0
assay format 2 0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine