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Target Snapshot

CHEMBL613629 Target Snapshot

Heart · TISSUE · Rattus norvegicus

Back to Search Search this target Browse approvals Evidence Card
321Compounds
502Assays
4Approved Drugs
42.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Heart as ChEMBL target CHEMBL613629. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Heart
TISSUE · Rattus norvegicus
As of 2026-09-14
ChEMBL target ID
CHEMBL613629
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Heart still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

Jump to Disease Context
Need a meeting-ready explanation of why this target matters?
Evidence Card
Review-ready rationale with source-aware context

Open the one-page evidence card when you want the rationale, activity base, and attribution together.

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameHeart
Target TypeTISSUE
OrganismRattus norvegicus
ChEMBL ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelHeart
UniProt AccessionN/A

Heart

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Heart.

Review nameHeart
OrganismRattus norvegicus
Clinical Profile

Clinical Phase Distribution

4
Approved
Assay Mix

Activity Type Distribution

IC5015.0
EC5027.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL3609819 8.15 EC50 7.0 Preclinical
CHEMBL3608316 7.8 EC50 16.0 Preclinical
CHEMBL3608941 7.7 EC50 20.0 Preclinical
CHEMBL3609822 7.7 EC50 20.0 Preclinical
CHEMBL3609818 7.66 EC50 22.0 Preclinical
CHEMBL3609824 7.64 EC50 23.0 Preclinical
CHEMBL3608947 7.58 EC50 26.0 Preclinical
CHEMBL3609817 7.58 EC50 26.0 Preclinical
CHEMBL45816 7.58 EC50 26.0 Approved
CHEMBL3609825 7.54 EC50 29.0 Preclinical
Distribution

pChEMBL Value Distribution

7
5.0
0
5.5
0
6.0
5
6.5
6
7.0
9
7.5
1
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

RIOCIGUAT
CHEMBL2107834
Approved 2013
Properties Compare Identifier
MIBEFRADIL
CHEMBL45816
Approved 1997
Properties Compare Identifier
Assay Landscape

Assay Landscape

502
Total Assays
36
Tested Compounds
3
Assay Types
ADME — 271 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
organism-based format 262 0 —
tissue-based format 9 0 —
Toxicity — 123 assays, 1 compounds
BAO Format Assays Compounds Avg pChEMBL
tissue-based format 122 1 5.0
assay format 1 0 —
Functional — 108 assays, 36 compounds
BAO Format Assays Compounds Avg pChEMBL
tissue-based format 104 36 6.4
organism-based format 4 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine