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Target Snapshot

CHEMBL613690 Target Snapshot

Hepatocyte · CELL-LINE · Homo sapiens

Back to Search Search this target Browse approvals Evidence Card
1,986Compounds
946Assays
6Approved Drugs
83.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Hepatocyte as ChEMBL target CHEMBL613690. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Hepatocyte
CELL-LINE · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL613690
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Hepatocyte still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

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Need a meeting-ready explanation of why this target matters?
Evidence Card
Review-ready rationale with source-aware context

Open the one-page evidence card when you want the rationale, activity base, and attribution together.

Open Review-ready Card
Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameHepatocyte
Target TypeCELL-LINE
OrganismHomo sapiens
ChEMBL ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelHepatocyte
UniProt AccessionN/A

Hepatocyte

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Hepatocyte.

Review nameHepatocyte
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

6
Approved
2
Phase III
Assay Mix

Activity Type Distribution

IC5058.0
EC5025.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL466326 8.77 IC50 1.7 Preclinical
CHEMBL3125702 8.2 IC50 6.3 Clinical
CHEMBL3125537 7.8 IC50 16.0 Preclinical
CHEMBL3407554 7.58 IC50 26.0 Preclinical
CHEMBL3407555 7.57 IC50 27.0 Preclinical
CHEMBL455323 6.16 IC50 700.0 Preclinical
CHEMBL374478 6.01 EC50 980.0 Approved
CHEMBL105 5.84 EC50 1460.0 Approved
CHEMBL135 5.72 EC50 1900.0 Approved
CHEMBL5590333 5.6 IC50 2500.0 Preclinical
Distribution

pChEMBL Value Distribution

10
5.0
5
5.5
2
6.0
0
6.5
0
7.0
3
7.5
1
8.0
1
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

RIFAMPIN
CHEMBL374478
Approved 1971
Properties Compare Identifier
Assay Landscape

Assay Landscape

952
Total Assays
27
Tested Compounds
3
Assay Types
ADME — 894 assays, 27 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 894 27 5.0
Toxicity — 35 assays, 9 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 35 9 5.0
Functional — 23 assays, 8 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 23 8 5.9

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine