Skip to main content
Free research Free research Free target review with research home and workspace preview
Quick search ChEMBL 36
Loading Target Snapshot...
Querying ChEMBL database. This may take a few seconds.
Target Snapshot

CHEMBL613704 Target Snapshot

MX1 · CELL-LINE · Homo sapiens

678Compounds
346Assays
10Approved Drugs
636.0Activities
Free Research Context

Research home keeps recent targets

This target will appear in recent viewed items on this browser. Use the demo workspace to preview watch rules and decision queues.

Navigation

Switch target

Move to another high-traffic target or paste a specific ChEMBL target ID.

Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats MX1 as ChEMBL target CHEMBL613704. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
MX1
CELL-LINE · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL613704
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether MX1 still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

Jump to Disease Context
Need a meeting-ready explanation of why this target matters?
Evidence Card
Review-ready rationale with source-aware context

Open the one-page evidence card when you want the rationale, activity base, and attribution together.

Open Review-ready Card
Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelMX1
UniProt AccessionN/A

MX1

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as MX1.

Review nameMX1
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

10
Approved
1
Phase III
2
Phase II
1
Phase I
Assay Mix

Activity Type Distribution

IC50477.0
EC50159.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL3137320 9.52 EC50 0.3 Approved
CHEMBL5406119 9.19 IC50 0.65 Preclinical
CHEMBL4212498 9.14 EC50 0.72 Preclinical
CHEMBL5423934 8.93 IC50 1.18 Preclinical
CHEMBL4208129 8.89 EC50 1.3 Preclinical
CHEMBL4208136 8.85 EC50 1.4 Preclinical
CHEMBL4215988 8.85 EC50 1.4 Preclinical
CHEMBL5434732 8.78 IC50 1.67 Preclinical
CHEMBL3298846 8.73 IC50 1.88 Preclinical
CHEMBL126916 8.72 IC50 1.89 Preclinical
Distribution

pChEMBL Value Distribution

79
5.0
78
5.5
74
6.0
52
6.5
64
7.0
57
7.5
51
8.0
20
8.5
2
9.0
1
9.5
pChEMBL
Approved Drugs

Approved Drugs

TALAZOPARIB
CHEMBL3137320
Approved 2018
RUCAPARIB
CHEMBL1173055
Approved 2016
OLAPARIB
CHEMBL521686
Approved 2014
PACLITAXEL
CHEMBL428647
Approved 1992
DOXORUBICIN
CHEMBL53463
Approved 1974
VINBLASTINE
CHEMBL159
Approved 1965
VINCRISTINE
CHEMBL90555
Approved 1963
Assay Landscape

Assay Landscape

350
Total Assays
491
Tested Compounds
2
Assay Types
Functional — 349 assays, 491 compounds
BAO Format Assays Compounds Avg pChEMBL
organism-based format 238 0
cell-based format 111 491 6.5
Unassigned — 1 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 1 0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine