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Target Snapshot

CHEMBL613706 Target Snapshot

PMNL · CELL-LINE

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17Compounds
11Assays
0Approved Drugs
20.0Activities
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Move to another high-traffic target or paste a specific ChEMBL target ID.

Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats PMNL as ChEMBL target CHEMBL613706. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
PMNL
CELL-LINE
As of 2026-09-13
ChEMBL target ID
CHEMBL613706
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether PMNL still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

Jump to Disease Context
Need a meeting-ready explanation of why this target matters?
Evidence Card
Review-ready rationale with source-aware context

Open the one-page evidence card when you want the rationale, activity base, and attribution together.

Open Review-ready Card
Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NamePMNL
Target TypeCELL-LINE
OrganismNone
ChEMBL ↗

Next Actions

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelPMNL
UniProt AccessionN/A

PMNL

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as PMNL.

Review namePMNL
Clinical Profile

Clinical Phase Distribution

1
Phase II
Assay Mix

Activity Type Distribution

IC5020.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL379761 6.62 IC50 240.0 Preclinical
CHEMBL52 6.4 IC50 400.0 Preclinical
CHEMBL205654 6.1 IC50 794.33 Preclinical
CHEMBL208884 5.7 IC50 2000.0 Preclinical
CHEMBL173395 5.22 IC50 6000.0 Preclinical
CHEMBL3289931 5.16 IC50 7000.0 Preclinical
CHEMBL367741 5.1 IC50 8000.0 Preclinical
CHEMBL490329 5.05 IC50 9000.0 Preclinical
CHEMBL46469 4.43 IC50 37000.0 Clinical
CHEMBL493032 4.4 IC50 40000.0 Preclinical
Distribution

pChEMBL Value Distribution

4
5.0
3
5.5
3
6.0
1
6.5
0
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

11
Total Assays
11
Tested Compounds
1
Assay Types
Functional — 11 assays, 11 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 11 11 5.5

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine