Skip to main content
Free research Free research Free target review with research home and workspace preview
Quick search ChEMBL 36
Loading Target Snapshot...
Querying ChEMBL database. This may take a few seconds.
Target Snapshot

CHEMBL613710 Target Snapshot

Neutrophil · CELL-LINE

Back to Search Search this target Browse approvals Evidence Card
780Compounds
317Assays
5Approved Drugs
863.0Activities
Free Research Context

Research home keeps recent targets

This target will appear in recent viewed items on this browser. Use the demo workspace to preview watch rules and decision queues.

Research home Demo workspace
Navigation

Switch target

Move to another high-traffic target or paste a specific ChEMBL target ID.

Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Neutrophil as ChEMBL target CHEMBL613710. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Neutrophil
CELL-LINE
As of 2026-09-13
ChEMBL target ID
CHEMBL613710
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Neutrophil still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

Jump to Disease Context
Need a meeting-ready explanation of why this target matters?
Evidence Card
Review-ready rationale with source-aware context

Open the one-page evidence card when you want the rationale, activity base, and attribution together.

Open Review-ready Card
Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameNeutrophil
Target TypeCELL-LINE
OrganismNone
ChEMBL ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelNeutrophil
UniProt AccessionN/A

Neutrophil

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Neutrophil.

Review nameNeutrophil
Clinical Profile

Clinical Phase Distribution

5
Approved
2
Phase III
4
Phase II
1
Phase I
Assay Mix

Activity Type Distribution

IC50842.0
EC5021.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL511751 10.7 IC50 0.02 Preclinical
CHEMBL160 10.33 IC50 0.047 Approved
CHEMBL513307 10.26 IC50 0.0546 Preclinical
CHEMBL467717 10.05 IC50 0.09 Preclinical
CHEMBL1094346 10.0 IC50 0.1 Preclinical
CHEMBL1098560 10.0 IC50 0.1 Preclinical
CHEMBL468124 10.0 IC50 0.1 Preclinical
CHEMBL467923 9.74 IC50 0.18 Preclinical
CHEMBL466493 9.72 IC50 0.19 Preclinical
CHEMBL468536 9.7 IC50 0.2 Preclinical
Distribution

pChEMBL Value Distribution

125
5.0
113
5.5
65
6.0
34
6.5
47
7.0
21
7.5
15
8.0
6
8.5
8
9.0
7
9.5
pChEMBL
Approved Drugs

Approved Drugs

CANNABIDIOL
CHEMBL190461
Approved 2018
Properties Compare Identifier
IDELALISIB
CHEMBL2216870
Approved 2014
Properties Compare Identifier
CYCLOSPORINE
CHEMBL160
Approved 1983
Properties Compare Identifier
Assay Landscape

Assay Landscape

317
Total Assays
421
Tested Compounds
3
Assay Types
Functional — 287 assays, 421 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 286 420 5.9
cell-free format 1 1 7.4
Toxicity — 22 assays, 1 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 22 1 4.5
ADME — 8 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 8 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine