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Target Snapshot

CHEMBL613824 Target Snapshot

CNE · CELL-LINE · Homo sapiens

Back to Search Search this target Browse approvals Evidence Card
298Compounds
37Assays
3Approved Drugs
284.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats CNE as ChEMBL target CHEMBL613824. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
CNE
CELL-LINE · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL613824
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether CNE still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

Jump to Disease Context
Need a meeting-ready explanation of why this target matters?
Evidence Card
Review-ready rationale with source-aware context

Open the one-page evidence card when you want the rationale, activity base, and attribution together.

Open Review-ready Card
Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameCNE
Target TypeCELL-LINE
OrganismHomo sapiens
ChEMBL ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelCNE
UniProt AccessionN/A

CNE

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as CNE.

Review nameCNE
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

3
Approved
2
Phase III
1
Phase II
Assay Mix

Activity Type Distribution

IC50284.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL53463 6.66 IC50 220.0 Approved
CHEMBL65 6.47 IC50 340.0 Preclinical
CHEMBL9470 6.16 IC50 700.0 Preclinical
CHEMBL3331593 5.91 IC50 1240.0 Preclinical
CHEMBL4530108 5.9 IC50 1260.0 Preclinical
CHEMBL4288799 5.72 IC50 1890.0 Preclinical
CHEMBL5279000 5.68 IC50 2100.0 Preclinical
CHEMBL271295 5.62 IC50 2400.0 Preclinical
CHEMBL3331595 5.44 IC50 3630.0 Preclinical
CHEMBL3331594 5.42 IC50 3810.0 Preclinical
Distribution

pChEMBL Value Distribution

13
5.0
5
5.5
2
6.0
1
6.5
0
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

DOXORUBICIN
CHEMBL53463
Approved 1974
Properties Compare Identifier
Assay Landscape

Assay Landscape

37
Total Assays
132
Tested Compounds
1
Assay Types
Functional — 37 assays, 132 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 37 132 4.6

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine