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Target Snapshot

CHEMBL613837 Target Snapshot

Human coronavirus 229E · ORGANISM · Human coronavirus 229E

251Compounds
61Assays
8Approved Drugs
220.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

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Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Human coronavirus 229E as ChEMBL target CHEMBL613837. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Human coronavirus 229E
ORGANISM · Human coronavirus 229E
As of 2026-09-13
ChEMBL target ID
CHEMBL613837
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Human coronavirus 229E still has a stable protein naming contract across sources.

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Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelHuman coronavirus 229E
UniProt AccessionN/A

Human coronavirus 229E

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Human coronavirus 229E.

Review nameHuman coronavirus 229E
OrganismHuman coronavirus 229E
Clinical Profile

Clinical Phase Distribution

8
Approved
3
Phase III
1
Phase II
1
Phase I
Assay Mix

Activity Type Distribution

IC5020.0
KI2.0
EC50198.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL91704 8.83 IC50 1.48 Clinical
CHEMBL5595779 8.7 EC50 2.0 Preclinical
CHEMBL555196 8.52 EC50 3.0 Preclinical
CHEMBL5583975 8.3 EC50 5.0 Preclinical
CHEMBL5583748 8.15 EC50 7.0 Preclinical
CHEMBL4777223 8.05 EC50 9.0 Preclinical
CHEMBL5189954 7.89 EC50 13.0 Preclinical
CHEMBL5182995 7.89 IC50 13.0 Preclinical
CHEMBL5191464 7.68 EC50 21.0 Preclinical
CHEMBL4065616 7.62 EC50 24.0 Approved
Distribution

pChEMBL Value Distribution

38
5.0
24
5.5
9
6.0
13
6.5
12
7.0
11
7.5
3
8.0
4
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

NIRMATRELVIR
CHEMBL4802135
Approved 2023
REMDESIVIR
CHEMBL4065616
Approved 2020
Assay Landscape

Assay Landscape

61
Total Assays
115
Tested Compounds
1
Assay Types
Functional — 61 assays, 115 compounds
BAO Format Assays Compounds Avg pChEMBL
organism-based format 60 113 5.9
cell-based format 1 2 4.4

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine