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Target Snapshot

CHEMBL613870 Target Snapshot

BT-20 · CELL-LINE · Homo sapiens

393Compounds
135Assays
22Approved Drugs
307.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats BT-20 as ChEMBL target CHEMBL613870. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
BT-20
CELL-LINE · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL613870
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether BT-20 still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelBT-20
UniProt AccessionN/A

BT-20

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as BT-20.

Review nameBT-20
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

22
Approved
9
Phase III
14
Phase II
4
Phase I
Assay Mix

Activity Type Distribution

IC50303.0
EC504.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL198075 8.52 IC50 3.0 Preclinical
CHEMBL217666 8.47 IC50 3.4 Preclinical
CHEMBL3545252 8.43 IC50 3.758 Approved
CHEMBL1627071 8.3 IC50 5.0 Preclinical
CHEMBL94657 8.29 IC50 5.097 Clinical
CHEMBL253178 8.0 IC50 10.0 Preclinical
CHEMBL265005 7.95 IC50 11.3 Preclinical
CHEMBL553025 7.91 IC50 12.36 Approved
CHEMBL217667 7.9 IC50 12.6 Preclinical
CHEMBL254849 7.7 IC50 20.0 Preclinical
Distribution

pChEMBL Value Distribution

36
5.0
31
5.5
13
6.0
7
6.5
8
7.0
6
7.5
5
8.0
1
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

TEMSIROLIMUS
CHEMBL1201182
Approved 2007
GEMCITABINE
CHEMBL888
Approved 1996
DOCETAXEL
CHEMBL3545252
Approved 1995
VINORELBINE
CHEMBL553025
Approved 1994
MITOMYCIN
CHEMBL105
Approved 1981
VINBLASTINE
CHEMBL159
Approved 1965
Assay Landscape

Assay Landscape

135
Total Assays
242
Tested Compounds
1
Assay Types
Functional — 135 assays, 242 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 127 242 5.4
organism-based format 8 0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine