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Target Snapshot

CHEMBL613897 Target Snapshot

Ferriprotoporphyrin IX · SMALL MOLECULE · Plasmodium falciparum

117Compounds
24Assays
1Approved Drugs
33.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Ferriprotoporphyrin IX shows approved-linked disease relevance led by malaria. 5 more disease programs remain visible in the same review block. 7 linked drugs keep the current disease frame grounded. Use malaria as the disease frame, then confirm a stable protein accession before cross-source reuse.

Review focus
Disease frame ready

Use malaria as the disease frame, then confirm a stable protein accession before cross-source reuse.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14 7 linked drugs
Open source guide
Disease program
malaria

Ferriprotoporphyrin IX shows approved-linked disease relevance led by malaria. 5 more disease programs remain visible in the same review block. 7 linked drugs remain visible in the same block.

Start review with malaria because it currently carries approved-linked support. Linked drugs include ARTEMETHER, ARTENIMOL, CHLOROQUINE PHOSPHATE, HYDROXYCHLOROQUINE SULFATE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Disease source · ChEMBL drug mechanism + indication proxy
Approved-linked Open Targets-ready proxy 7 linked drugs
Open disease block
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Ferriprotoporphyrin IX as ChEMBL target CHEMBL613897. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Ferriprotoporphyrin IX
SMALL MOLECULE · Plasmodium falciparum
As of 2026-09-14
ChEMBL target ID
CHEMBL613897
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Ferriprotoporphyrin IX still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need to confirm why malaria is currently framed as approved-linked support. It currently carries 7 linked drugs in the same disease frame.

Jump to Disease Context
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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelFerriprotoporphyrin IX
UniProt AccessionN/A

Ferriprotoporphyrin IX

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Ferriprotoporphyrin IX.

Review nameFerriprotoporphyrin IX
OrganismPlasmodium falciparum
Disease Relevance

Disease Relevance & Evidence Level

Open Targets-ready disease context using the current target-indication evidence contract.

Approved-linked Open Targets-ready proxy

Ferriprotoporphyrin IX shows approved-linked disease relevance led by malaria. 5 more disease programs remain visible in the same review block.

Approved-linked Approved
malaria
7 linked drugs · 7 direct · 7 efficacy
Linked drugARTEMETHER
Linked drugARTENIMOL
Linked drugCHLOROQUINE PHOSPHATE
Linked drugHYDROXYCHLOROQUINE SULFATE
Approved-linked Approved
Plasmodium falciparum malaria
6 linked drugs · 6 direct · 6 efficacy
Linked drugARTEMETHER
Linked drugARTENIMOL
Linked drugLUMEFANTRINE
Linked drugMEFLOQUINE HYDROCHLORIDE
Approved-linked Approved
Plasmodium vivax malaria
5 linked drugs · 5 direct · 5 efficacy
Linked drugARTEMETHER
Linked drugARTENIMOL
Linked drugLUMEFANTRINE
Linked drugMEFLOQUINE HYDROCHLORIDE
Approved-linked Approved
rheumatoid arthritis
3 linked drugs · 3 direct · 3 efficacy
Linked drugCHLOROQUINE HYDROCHLORIDE
Linked drugCHLOROQUINE PHOSPHATE
Linked drugHYDROXYCHLOROQUINE SULFATE
Approved-linked Approved
muscle cramp
1 linked drug · 1 direct · 1 efficacy
Linked drugQUININE SULFATE
Late clinical Phase III
Fever
4 linked drugs · 4 direct · 4 efficacy
Linked drugARTEMETHER
Linked drugARTENIMOL
Linked drugLUMEFANTRINE
Linked drugPIPERAQUINE
Source · ChEMBL drug mechanism + indication proxy
Review Cue

How to read disease relevance

Start review with malaria because it currently carries approved-linked support. Linked drugs include ARTEMETHER, ARTENIMOL, CHLOROQUINE PHOSPHATE, HYDROXYCHLOROQUINE SULFATE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Lead diseasemalaria
Strongest levelApproved-linked
Block modeOpen Targets-ready proxy
Clinical Profile

Clinical Phase Distribution

1
Approved
Assay Mix

Activity Type Distribution

IC5033.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL76 4.75 IC50 17900.0 Approved
Distribution

pChEMBL Value Distribution

0
5.0
0
5.5
0
6.0
0
6.5
0
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

24
Total Assays
16
Tested Compounds
2
Assay Types
Binding — 15 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 15 0
Functional — 9 assays, 16 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 9 16 4.7

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine