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Target Snapshot

CHEMBL613988 Target Snapshot

Kasumi 1 · CELL-LINE · Homo sapiens

462Compounds
114Assays
24Approved Drugs
409.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-12

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-12
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Kasumi 1 as ChEMBL target CHEMBL613988. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Kasumi 1
CELL-LINE · Homo sapiens
As of 2026-09-12
ChEMBL target ID
CHEMBL613988
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-12
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-12
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Kasumi 1 still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelKasumi 1
UniProt AccessionN/A

Kasumi 1

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Kasumi 1.

Review nameKasumi 1
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

24
Approved
5
Phase III
13
Phase II
3
Phase I
Assay Mix

Activity Type Distribution

IC50395.0
EC5014.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL2041933 9.63 IC50 0.2339 Preclinical
CHEMBL4170596 9.1 IC50 0.8 Preclinical
CHEMBL4650360 8.7 EC50 2.0 Clinical
CHEMBL4650360 8.7 IC50 2.0 Clinical
CHEMBL1171837 8.66 IC50 2.174 Approved
CHEMBL5592221 8.4 IC50 3.99 Preclinical
CHEMBL428647 8.4 IC50 4.0 Approved
CHEMBL65 8.39 IC50 4.066 Preclinical
CHEMBL3545252 8.29 IC50 5.11 Approved
CHEMBL3987016 8.2 IC50 6.3 Clinical
Distribution

pChEMBL Value Distribution

66
5.0
87
5.5
57
6.0
24
6.5
15
7.0
17
7.5
12
8.0
3
8.5
1
9.0
1
9.5
pChEMBL
Approved Drugs

Approved Drugs

ALPELISIB
CHEMBL2396661
Approved 2019
MIDOSTAURIN
CHEMBL608533
Approved 2017
VENETOCLAX
CHEMBL3137309
Approved 2016
AFATINIB
CHEMBL1173655
Approved 2013
BOSUTINIB
CHEMBL288441
Approved 2012
AXITINIB
CHEMBL1289926
Approved 2012
PONATINIB
CHEMBL1171837
Approved 2012
NILOTINIB
CHEMBL255863
Approved 2007
TEMSIROLIMUS
CHEMBL1201182
Approved 2007
SUNITINIB
CHEMBL535
Approved 2006
VORINOSTAT
CHEMBL98
Approved 2006
SORAFENIB
CHEMBL1336
Approved 2005
GEFITINIB
CHEMBL939
Approved 2003
DOCETAXEL
CHEMBL3545252
Approved 1995
VINORELBINE
CHEMBL553025
Approved 1994
PACLITAXEL
CHEMBL428647
Approved 1992
DIGOXIN
CHEMBL1751
Approved 1975
VINBLASTINE
CHEMBL159
Approved 1965
Assay Landscape

Assay Landscape

114
Total Assays
332
Tested Compounds
1
Assay Types
Functional — 114 assays, 332 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 98 332 6.0
organism-based format 16 0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine