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Target Snapshot

CHEMBL613997 Target Snapshot

KU812 cell line · CELL-LINE · Homo sapiens

178Compounds
57Assays
32Approved Drugs
170.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats KU812 cell line as ChEMBL target CHEMBL613997. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
KU812 cell line
CELL-LINE · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL613997
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether KU812 cell line still has a stable protein naming contract across sources.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelKU812 cell line
UniProt AccessionN/A

KU812 cell line

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as KU812 cell line.

Review nameKU812 cell line
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

32
Approved
13
Phase III
11
Phase II
5
Phase I
Assay Mix

Activity Type Distribution

IC50157.0
EC5013.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL5416410 10.0 IC50 0.1 Approved
CHEMBL5093894 10.0 IC50 0.1 Preclinical
CHEMBL1171837 10.0 IC50 0.1 Approved
CHEMBL5089813 9.7 IC50 0.2 Preclinical
CHEMBL5089020 9.7 IC50 0.2 Preclinical
CHEMBL5083651 9.4 IC50 0.4 Preclinical
CHEMBL255863 8.74 IC50 1.8 Approved
CHEMBL888 8.72 IC50 1.913 Approved
CHEMBL413 8.7 IC50 2.013 Approved
CHEMBL96926 8.67 IC50 2.118 Preclinical
Distribution

pChEMBL Value Distribution

21
5.0
13
5.5
10
6.0
12
6.5
11
7.0
15
7.5
16
8.0
7
8.5
1
9.0
2
9.5
pChEMBL
Approved Drugs

Approved Drugs

SELUMETINIB
CHEMBL1614701
Approved 2020
AFATINIB
CHEMBL1173655
Approved 2013
PONATINIB
CHEMBL1171837
Approved 2012
BOSUTINIB
CHEMBL288441
Approved 2012
AXITINIB
CHEMBL1289926
Approved 2012
NILOTINIB
CHEMBL255863
Approved 2007
DASATINIB
CHEMBL5416410
Approved 2006
VORINOSTAT
CHEMBL98
Approved 2006
IMATINIB
CHEMBL941
Approved 2001
IMATINIB MESYLATE
CHEMBL1642
Approved 2001
SIROLIMUS
CHEMBL413
Approved 1999
GEMCITABINE
CHEMBL888
Approved 1996
DOCETAXEL
CHEMBL3545252
Approved 1995
VINORELBINE
CHEMBL553025
Approved 1994
PACLITAXEL
CHEMBL428647
Approved 1992
MITOMYCIN
CHEMBL105
Approved 1981
DOXORUBICIN
CHEMBL53463
Approved 1974
TRETINOIN
CHEMBL38
Approved 1971
VINBLASTINE
CHEMBL159
Approved 1965
Assay Landscape

Assay Landscape

57
Total Assays
160
Tested Compounds
1
Assay Types
Functional — 57 assays, 160 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 56 160 6.3
organism-based format 1 0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine