cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A · SINGLE PROTEIN · Rattus norvegicus
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As of 2026-09-14Protein identity stays anchored to UniProt Q9QYJ6. Use UniProt Q9QYJ6 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q9QYJ6 as the stable identity anchor, then attach disease evidence before program review.
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
Review this target as cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, mapped to UniProt Q9QYJ6. Sequence length is 794 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A as ChEMBL target CHEMBL6140, mapped to UniProt Q9QYJ6. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A |
| Target Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
| UniProt | Q9QYJ6 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A |
| UniProt Accession | Q9QYJ6 |
| Component Type | Protein |
| Sequence Length | 794 aa |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
Review this target as cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, mapped to UniProt Q9QYJ6. Sequence length is 794 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL3660647 | 10.4 | IC50 | 0.04 | Preclinical |
| CHEMBL2180802 | 10.35 | IC50 | 0.045 | Preclinical |
| CHEMBL3660644 | 10.26 | IC50 | 0.055 | Preclinical |
| CHEMBL3660645 | 10.25 | IC50 | 0.056 | Preclinical |
| CHEMBL3695530 | 10.16 | IC50 | 0.0697 | Preclinical |
| CHEMBL3695526 | 10.08 | IC50 | 0.0837 | Preclinical |
| CHEMBL3691443 | 10.05 | IC50 | 0.0896 | Preclinical |
| CHEMBL3695520 | 10.02 | IC50 | 0.095 | Preclinical |
| CHEMBL3906366 | 10.01 | IC50 | 0.098 | Preclinical |
| CHEMBL3691421 | 10.0 | IC50 | 0.101 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 19 | 454 | 7.4 |
| single protein format | 13 | 500 | 7.5 |
| tissue-based format | 3 | 2 | 8.4 |
| assay format | 1 | 351 | 7.1 |