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Target Snapshot

CHEMBL614023 Target Snapshot

A2780cisR · CELL-LINE · Homo sapiens

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87Compounds
55Assays
2Approved Drugs
89.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats A2780cisR as ChEMBL target CHEMBL614023. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
A2780cisR
CELL-LINE · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL614023
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether A2780cisR still has a stable protein naming contract across sources.

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Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameA2780cisR
Target TypeCELL-LINE
OrganismHomo sapiens
ChEMBL ↗

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelA2780cisR
UniProt AccessionN/A

A2780cisR

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as A2780cisR.

Review nameA2780cisR
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

2
Approved
Assay Mix

Activity Type Distribution

IC5089.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL4458738 9.62 IC50 0.24 Preclinical
CHEMBL5562521 9.55 IC50 0.28 Preclinical
CHEMBL53463 8.22 IC50 6.0 Approved
CHEMBL5177129 7.82 IC50 15.0 Preclinical
CHEMBL105 7.22 IC50 60.0 Approved
CHEMBL78703 7.12 IC50 76.0 Preclinical
CHEMBL146276 7.04 IC50 91.0 Preclinical
CHEMBL190451 7.0 IC50 100.0 Preclinical
CHEMBL372231 7.0 IC50 100.0 Preclinical
CHEMBL178282 6.96 IC50 110.0 Preclinical
Distribution

pChEMBL Value Distribution

16
5.0
22
5.5
13
6.0
9
6.5
5
7.0
2
7.5
1
8.0
0
8.5
0
9.0
2
9.5
pChEMBL
Approved Drugs

Approved Drugs

MITOMYCIN
CHEMBL105
Approved 1981
Properties Compare Identifier
DOXORUBICIN
CHEMBL53463
Approved 1974
Properties Compare Identifier
Assay Landscape

Assay Landscape

56
Total Assays
75
Tested Compounds
1
Assay Types
Functional — 56 assays, 75 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 56 75 6.0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine