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Target Snapshot

CHEMBL614038 Target Snapshot

HOS-TE85 · CELL-LINE · Homo sapiens

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196Compounds
60Assays
4Approved Drugs
196.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats HOS-TE85 as ChEMBL target CHEMBL614038. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
HOS-TE85
CELL-LINE · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL614038
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether HOS-TE85 still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

Jump to Disease Context
Need a meeting-ready explanation of why this target matters?
Evidence Card
Review-ready rationale with source-aware context

Open the one-page evidence card when you want the rationale, activity base, and attribution together.

Open Review-ready Card
Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameHOS-TE85
Target TypeCELL-LINE
OrganismHomo sapiens
ChEMBL ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelHOS-TE85
UniProt AccessionN/A

HOS-TE85

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as HOS-TE85.

Review nameHOS-TE85
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

4
Approved
2
Phase III
Assay Mix

Activity Type Distribution

IC50196.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL5564715 8.4 IC50 4.0 Preclinical
CHEMBL2103840 8.26 IC50 5.5 Clinical
CHEMBL5557168 8.22 IC50 6.0 Preclinical
CHEMBL5200417 8.06 IC50 8.8 Preclinical
CHEMBL5561646 8.05 IC50 9.0 Preclinical
CHEMBL5203662 7.85 IC50 14.2 Preclinical
CHEMBL5204316 7.8 IC50 15.9 Preclinical
CHEMBL5542595 7.8 IC50 16.0 Preclinical
CHEMBL5209860 7.79 IC50 16.2 Preclinical
CHEMBL5564728 7.77 IC50 17.0 Preclinical
Distribution

pChEMBL Value Distribution

5
5.0
13
5.5
15
6.0
29
6.5
30
7.0
21
7.5
5
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

DOXORUBICIN
CHEMBL53463
Approved 1974
Properties Compare Identifier
Assay Landscape

Assay Landscape

60
Total Assays
131
Tested Compounds
1
Assay Types
Functional — 60 assays, 131 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 49 131 6.6
organism-based format 11 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine