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Target Snapshot

CHEMBL614039 Target Snapshot

Huh-7 · CELL-LINE · Homo sapiens

11,800Compounds
1,504Assays
39Approved Drugs
2,570.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Huh-7 as ChEMBL target CHEMBL614039. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Huh-7
CELL-LINE · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL614039
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Huh-7 still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

Jump to Disease Context
Need a meeting-ready explanation of why this target matters?
Evidence Card
Review-ready rationale with source-aware context

Open the one-page evidence card when you want the rationale, activity base, and attribution together.

Open Review-ready Card
Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelHuh-7
UniProt AccessionN/A

Huh-7

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Huh-7.

Review nameHuh-7
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

39
Approved
20
Phase III
19
Phase II
4
Phase I
Assay Mix

Activity Type Distribution

IC502,229.0
EC50341.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL96926 9.62 IC50 0.2396 Preclinical
CHEMBL65 9.49 IC50 0.32 Preclinical
CHEMBL4475995 9.28 IC50 0.525 Preclinical
CHEMBL4161911 9.08 IC50 0.83 Preclinical
CHEMBL4789173 9.0 IC50 1.0 Preclinical
CHEMBL1336 9.0 IC50 1.0 Approved
CHEMBL566757 8.98 IC50 1.05 Clinical
CHEMBL4446479 8.7 IC50 2.0 Preclinical
CHEMBL428647 8.7 IC50 2.0 Approved
CHEMBL3356793 8.68 IC50 2.1 Preclinical
Distribution

pChEMBL Value Distribution

385
5.0
344
5.5
204
6.0
120
6.5
167
7.0
75
7.5
29
8.0
11
8.5
5
9.0
1
9.5
pChEMBL
Approved Drugs

Approved Drugs

INFIGRATINIB
CHEMBL1852688
Approved 2021
LENVATINIB
CHEMBL1289601
Approved 2015
PONATINIB
CHEMBL1171837
Approved 2012
OMACETAXINE MEPESUCCINATE
CHEMBL46286
Approved 2009
TEMSIROLIMUS
CHEMBL1201182
Approved 2007
VORINOSTAT
CHEMBL98
Approved 2006
SORAFENIB
CHEMBL1336
Approved 2005
EPIRUBICIN
CHEMBL417
Approved 1999
GEMCITABINE
CHEMBL888
Approved 1996
DOCETAXEL
CHEMBL3545252
Approved 1995
VINORELBINE
CHEMBL553025
Approved 1994
CLADRIBINE
CHEMBL1619
Approved 1993
PACLITAXEL
CHEMBL428647
Approved 1992
DOXORUBICIN
CHEMBL53463
Approved 1974
VINBLASTINE
CHEMBL159
Approved 1965
VINCRISTINE
CHEMBL90555
Approved 1963
COLCHICINE
CHEMBL107
Approved 1961
Assay Landscape

Assay Landscape

1,505
Total Assays
1,687
Tested Compounds
3
Assay Types
Functional — 1,178 assays, 1,687 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 1,110 1,687 5.8
organism-based format 68 0
ADME — 251 assays, 21 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 249 21 5.1
organism-based format 2 0
Toxicity — 76 assays, 10 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 76 10 5.3

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine