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Target Snapshot

CHEMBL614062 Target Snapshot

N2a · CELL-LINE · Mus musculus

Back to Search Search this target Browse approvals Evidence Card
491Compounds
289Assays
2Approved Drugs
234.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats N2a as ChEMBL target CHEMBL614062. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
N2a
CELL-LINE · Mus musculus
As of 2026-09-13
ChEMBL target ID
CHEMBL614062
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether N2a still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

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Evidence Card
Review-ready rationale with source-aware context

Open the one-page evidence card when you want the rationale, activity base, and attribution together.

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameN2a
Target TypeCELL-LINE
OrganismMus musculus
ChEMBL ↗

Next Actions

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelN2a
UniProt AccessionN/A

N2a

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as N2a.

Review nameN2a
OrganismMus musculus
Clinical Profile

Clinical Phase Distribution

2
Approved
Assay Mix

Activity Type Distribution

IC50212.0
EC5022.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL1076252 10.04 IC50 0.092 Preclinical
CHEMBL388978 7.95 IC50 11.3 Preclinical
CHEMBL5279714 7.36 IC50 44.0 Preclinical
CHEMBL5273351 7.08 IC50 84.0 Preclinical
CHEMBL5438374 6.66 IC50 220.0 Preclinical
CHEMBL5421280 6.58 IC50 260.0 Preclinical
CHEMBL5406146 6.54 IC50 290.0 Preclinical
CHEMBL378225 6.44 IC50 360.0 Preclinical
CHEMBL5399312 6.4 IC50 400.0 Preclinical
CHEMBL5412156 6.35 IC50 450.0 Preclinical
Distribution

pChEMBL Value Distribution

23
5.0
23
5.5
14
6.0
3
6.5
2
7.0
1
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

289
Total Assays
81
Tested Compounds
3
Assay Types
Functional — 235 assays, 81 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 229 81 5.4
organism-based format 6 0 —
ADME — 40 assays, 19 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 40 19 4.7
Toxicity — 14 assays, 3 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 14 3 4.2

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine