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Target Snapshot

CHEMBL614072 Target Snapshot

BT-549 · CELL-LINE · Homo sapiens

28,760Compounds
1,165Assays
29Approved Drugs
891.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats BT-549 as ChEMBL target CHEMBL614072. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
BT-549
CELL-LINE · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL614072
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

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Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether BT-549 still has a stable protein naming contract across sources.

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Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelBT-549
UniProt AccessionN/A

BT-549

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as BT-549.

Review nameBT-549
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

29
Approved
12
Phase III
16
Phase II
6
Phase I
Assay Mix

Activity Type Distribution

IC50871.0
EC5020.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL265841 11.0 IC50 0.01 Preclinical
CHEMBL509175 10.7 IC50 0.02 Preclinical
CHEMBL428647 10.0 IC50 0.1 Approved
CHEMBL4525219 9.52 IC50 0.3 Preclinical
CHEMBL1823147 9.47 IC50 0.34 Preclinical
CHEMBL3128043 9.39 IC50 0.41 Preclinical
CHEMBL441158 9.0 IC50 1.0 Preclinical
CHEMBL67 8.77 IC50 1.71 Preclinical
CHEMBL38957 8.48 IC50 3.29 Preclinical
CHEMBL4540831 8.4 IC50 4.0 Preclinical
Distribution

pChEMBL Value Distribution

117
5.0
93
5.5
52
6.0
44
6.5
35
7.0
14
7.5
14
8.0
1
8.5
3
9.0
1
9.5
pChEMBL
Approved Drugs

Approved Drugs

GEMCITABINE
CHEMBL888
Approved 1996
CLADRIBINE
CHEMBL1619
Approved 1993
PACLITAXEL
CHEMBL428647
Approved 1992
ETOPOSIDE
CHEMBL44657
Approved 1983
DIGOXIN
CHEMBL1751
Approved 1975
DOXORUBICIN
CHEMBL53463
Approved 1974
CYTARABINE
CHEMBL803
Approved 1969
VINBLASTINE
CHEMBL159
Approved 1965
VINCRISTINE SULFATE
CHEMBL501867
Approved 1963
COLCHICINE
CHEMBL107
Approved 1961
Assay Landscape

Assay Landscape

1,165
Total Assays
543
Tested Compounds
2
Assay Types
Functional — 1,142 assays, 543 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 1,137 543 5.6
organism-based format 5 0
ADME — 23 assays, 12 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 23 12 4.9

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine