Acyl-CoA:cholesterol acyltransferase · SINGLE PROTEIN · Oryctolagus cuniculus
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As of 2026-09-14Protein identity stays anchored to UniProt Q95214. Use UniProt Q95214 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q95214 as the stable identity anchor, then attach disease evidence before program review.
Sterol O-acyltransferase 1
Review this target as Acyl-CoA:cholesterol acyltransferase, mapped to UniProt Q95214. ChEMBL maps the protein component as Sterol O-acyltransferase 1. Sequence length is 305 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Acyl-CoA:cholesterol acyltransferase as ChEMBL target CHEMBL6141, mapped to UniProt Q95214. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Acyl-CoA:cholesterol acyltransferase |
| Target Type | SINGLE PROTEIN |
| Organism | Oryctolagus cuniculus |
| UniProt | Q95214 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Sterol O-acyltransferase 1 |
| UniProt Accession | Q95214 |
| Component Type | Protein |
| Sequence Length | 305 aa |
Sterol O-acyltransferase 1
Review this target as Acyl-CoA:cholesterol acyltransferase, mapped to UniProt Q95214. ChEMBL maps the protein component as Sterol O-acyltransferase 1. Sequence length is 305 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL160103 | 8.4 | IC50 | 4.0 | Preclinical |
| CHEMBL164479 | 8.4 | IC50 | 4.0 | Preclinical |
| CHEMBL102026 | 8.22 | IC50 | 6.0 | Preclinical |
| CHEMBL422709 | 8.22 | IC50 | 6.0 | Preclinical |
| CHEMBL64237 | 8.22 | IC50 | 6.0 | Preclinical |
| CHEMBL101096 | 8.15 | IC50 | 7.0 | Preclinical |
| CHEMBL322919 | 8.15 | IC50 | 7.0 | Preclinical |
| CHEMBL353791 | 8.15 | IC50 | 7.0 | Preclinical |
| CHEMBL40608 | 8.15 | IC50 | 7.0 | Preclinical |
| CHEMBL309560 | 8.1 | IC50 | 8.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| microsome format | 23 | 371 | 6.9 |
| assay format | 21 | 355 | 6.7 |
| single protein format | 14 | 40 | 7.2 |
| tissue-based format | 9 | 169 | 6.6 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| organism-based format | 5 | 0 | — |
| microsome format | 2 | 22 | 7.0 |
| tissue-based format | 2 | 0 | — |
| assay format | 1 | 1 | 7.6 |