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Evidence Snapshot

PC-9

CHEMBL614102 CELL-LINE Homo sapiens
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T21:09:04Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL614102
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats PC-9 as ChEMBL target CHEMBL614102. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
PC-9
CELL-LINE · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL614102
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Review-ready Target Rationale

Why PC-9 matters

As of 2026-09-13

PC-9 is reviewed as PC-9; the current evidence base includes 19 approved drugs, 799 compounds, and 531 assays, with lead potency reaching pChEMBL 11.0.

Disease context
Disease signal

Disease relevance is not yet populated for this evidence card.

This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

ChEMBL target record
Activity base
Portfolio and assay base

ChEMBL currently tracks 19 approved drugs, 799 compounds, and 531 assays for this target. The dominant activity type is IC50. CHEMBL5593632 is the current potency anchor at pChEMBL 11.0.

Use CHEMBL5593632 as the tractability anchor when discussing potency (pChEMBL 11.0).

Activity source · ChEMBL 36 via Core Engine
19 approved pChEMBL 11.0
Source Guidance

Start with the right source

Pick the first block or linked source that matches the review question in front of you.

Need the shortest review narrative first?
Review-ready Target Rationale
One-page rationale with as-of-date and attribution

Start with the review rationale when you need to explain why PC-9 matters before drilling into raw source blocks.

Jump to Review Rationale
Need stable protein naming or accession mapping?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Go back to the target snapshot when you need the naming and mapping contract, not just the summarized rationale.

Open Protein Context
Need disease fit or evidence level for program framing?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use the target snapshot disease block when you need the disease program and supporting signals, not only the card summary.

Open Disease Context

Snapshot State

No project snapshot selected. Export uses the live evidence card state.

799
Total Compounds
531
Total Assays
19
Approved Drugs
IC50: 747.0, EC50: 88.0
Activity Types

pChEMBL Activity Distribution

Top 5 Inhibitors (by pChEMBL)

Structure Compound pChEMBL Type Phase
No preferred name
CHEMBL5593632
 11.0 IC50 —
No preferred name
CHEMBL3353410
 11.0 IC50 Approved
No preferred name
CHEMBL5594833
 10.7 IC50 —
No preferred name
CHEMBL5590430
 10.7 IC50 —
No preferred name
CHEMBL5284780
 10.7 IC50 —

Approved Drugs

Structure Compound First Approval
DACOMITINIB ANHYDROUS
CHEMBL2110732
 2018
BRIGATINIB
CHEMBL3545311
 2017
NERATINIB
CHEMBL180022
 2017
OSIMERTINIB
CHEMBL3353410
 2015
AFATINIB
CHEMBL1173655
 2013
ERLOTINIB
CHEMBL553
 2004
GEFITINIB
CHEMBL939
 2003
PACLITAXEL
CHEMBL428647
 1992
DOXORUBICIN
CHEMBL53463
 1974
← Target Page
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T21:09:04Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL614102