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Target Snapshot

CHEMBL614135 Target Snapshot

NCI-H358 · CELL-LINE · Homo sapiens

830Compounds
399Assays
32Approved Drugs
612.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats NCI-H358 as ChEMBL target CHEMBL614135. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
NCI-H358
CELL-LINE · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL614135
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether NCI-H358 still has a stable protein naming contract across sources.

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Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelNCI-H358
UniProt AccessionN/A

NCI-H358

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as NCI-H358.

Review nameNCI-H358
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

32
Approved
12
Phase III
10
Phase II
7
Phase I
Assay Mix

Activity Type Distribution

IC50532.0
EC5080.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL96926 9.54 IC50 0.2882 Preclinical
CHEMBL5618885 9.52 IC50 0.3 Preclinical
CHEMBL4594350 9.0 IC50 1.0 Approved
CHEMBL4535757 9.0 IC50 1.0 Approved
CHEMBL428647 8.7 IC50 2.0 Approved
CHEMBL94657 8.61 IC50 2.484 Clinical
CHEMBL4802043 8.52 IC50 3.0 Preclinical
CHEMBL5274267 8.45 IC50 3.56 Preclinical
CHEMBL1090479 8.4 EC50 4.0 Preclinical
CHEMBL107 8.4 IC50 4.0 Approved
Distribution

pChEMBL Value Distribution

108
5.0
79
5.5
77
6.0
36
6.5
31
7.0
31
7.5
30
8.0
4
8.5
3
9.0
2
9.5
pChEMBL
Approved Drugs

Approved Drugs

ADAGRASIB
CHEMBL4594350
Approved 2022
SOTORASIB
CHEMBL4535757
Approved 2021
ABEMACICLIB
CHEMBL3301610
Approved 2017
MIDOSTAURIN
CHEMBL608533
Approved 2017
AFATINIB
CHEMBL1173655
Approved 2013
PONATINIB
CHEMBL1171837
Approved 2012
TEMSIROLIMUS
CHEMBL1201182
Approved 2007
GEFITINIB
CHEMBL939
Approved 2003
GEMCITABINE
CHEMBL888
Approved 1996
DOCETAXEL
CHEMBL3545252
Approved 1995
VINORELBINE
CHEMBL553025
Approved 1994
PACLITAXEL
CHEMBL428647
Approved 1992
AMSACRINE
CHEMBL43
Approved 1987
MITOMYCIN
CHEMBL105
Approved 1981
DOXORUBICIN
CHEMBL53463
Approved 1974
VINBLASTINE
CHEMBL159
Approved 1965
COLCHICINE
CHEMBL107
Approved 1961
METHOTREXATE
CHEMBL34259
Approved 1953
Assay Landscape

Assay Landscape

399
Total Assays
495
Tested Compounds
3
Assay Types
Functional — 394 assays, 495 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 346 495 5.9
organism-based format 48 0
ADME — 3 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 3 0
Toxicity — 2 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 2 0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine