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Target Snapshot

CHEMBL614197 Target Snapshot

NCI-N87 · CELL-LINE · Homo sapiens

719Compounds
219Assays
28Approved Drugs
639.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats NCI-N87 as ChEMBL target CHEMBL614197. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
NCI-N87
CELL-LINE · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL614197
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether NCI-N87 still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelNCI-N87
UniProt AccessionN/A

NCI-N87

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as NCI-N87.

Review nameNCI-N87
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

28
Approved
15
Phase III
15
Phase II
6
Phase I
Assay Mix

Activity Type Distribution

IC50624.0
EC5015.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL4213013 10.47 IC50 0.034 Preclinical
CHEMBL5183440 10.0 IC50 0.1 Preclinical
CHEMBL4214485 9.82 IC50 0.152 Preclinical
CHEMBL5199279 9.77 IC50 0.17 Preclinical
CHEMBL4205723 9.31 IC50 0.486 Preclinical
CHEMBL5181694 9.25 IC50 0.56 Preclinical
CHEMBL4217429 9.25 IC50 0.559 Preclinical
CHEMBL4209576 9.21 IC50 0.621 Preclinical
CHEMBL3325463 9.19 IC50 0.641 Preclinical
CHEMBL180022 9.19 IC50 0.64 Approved
Distribution

pChEMBL Value Distribution

61
5.0
63
5.5
89
6.0
70
6.5
66
7.0
32
7.5
25
8.0
17
8.5
9
9.0
2
9.5
pChEMBL
Approved Drugs

Approved Drugs

ABEMACICLIB
CHEMBL3301610
Approved 2017
NERATINIB
CHEMBL180022
Approved 2017
PANOBINOSTAT
CHEMBL483254
Approved 2015
AFATINIB
CHEMBL1173655
Approved 2013
LAPATINIB
CHEMBL554
Approved 2007
LAPATINIB DITOSYLATE
CHEMBL1201179
Approved 2007
TEMSIROLIMUS
CHEMBL1201182
Approved 2007
GEFITINIB
CHEMBL939
Approved 2003
SIROLIMUS
CHEMBL413
Approved 1999
GEMCITABINE
CHEMBL888
Approved 1996
DOCETAXEL
CHEMBL3545252
Approved 1995
VINORELBINE
CHEMBL553025
Approved 1994
PACLITAXEL
CHEMBL428647
Approved 1992
MITOMYCIN
CHEMBL105
Approved 1981
DOXORUBICIN
CHEMBL53463
Approved 1974
VINBLASTINE
CHEMBL159
Approved 1965
COLCHICINE
CHEMBL107
Approved 1961
Assay Landscape

Assay Landscape

220
Total Assays
500
Tested Compounds
3
Assay Types
Functional — 217 assays, 500 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 157 500 6.4
organism-based format 60 0
ADME — 2 assays, 2 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 1 2 4.3
organism-based format 1 0
Unassigned — 1 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 1 0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine