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Target Snapshot

CHEMBL614198 Target Snapshot

NFF · CELL-LINE · Homo sapiens

Back to Search Search this target Browse approvals Evidence Card
315Compounds
71Assays
8Approved Drugs
297.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats NFF as ChEMBL target CHEMBL614198. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
NFF
CELL-LINE · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL614198
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether NFF still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

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Need a meeting-ready explanation of why this target matters?
Evidence Card
Review-ready rationale with source-aware context

Open the one-page evidence card when you want the rationale, activity base, and attribution together.

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameNFF
Target TypeCELL-LINE
OrganismHomo sapiens
ChEMBL ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelNFF
UniProt AccessionN/A

NFF

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as NFF.

Review nameNFF
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

8
Approved
1
Phase I
Assay Mix

Activity Type Distribution

IC50295.0
EC502.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL343448 9.0 IC50 1.0 Approved
CHEMBL428647 8.33 IC50 4.7 Approved
CHEMBL501867 7.77 IC50 16.9 Approved
CHEMBL4639966 7.3 IC50 50.0 Preclinical
CHEMBL483254 7.16 IC50 70.0 Approved
CHEMBL376909 7.09 IC50 81.0 Preclinical
CHEMBL53463 6.9 IC50 125.6 Approved
CHEMBL2208227 6.82 IC50 150.0 Preclinical
CHEMBL1289720 6.77 IC50 169.0 Preclinical
CHEMBL218097 6.72 IC50 190.0 Preclinical
Distribution

pChEMBL Value Distribution

34
5.0
26
5.5
21
6.0
10
6.5
5
7.0
2
7.5
1
8.0
0
8.5
1
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

PANOBINOSTAT
CHEMBL483254
Approved 2015
Properties Compare Identifier
ROMIDEPSIN
CHEMBL343448
Approved 2009
Properties Compare Identifier
PACLITAXEL
CHEMBL428647
Approved 1992
Properties Compare Identifier
DOXORUBICIN
CHEMBL53463
Approved 1974
Properties Compare Identifier
VINCRISTINE SULFATE
CHEMBL501867
Approved 1963
Properties Compare Identifier
Assay Landscape

Assay Landscape

71
Total Assays
83
Tested Compounds
3
Assay Types
Functional — 32 assays, 51 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 32 51 5.6
ADME — 31 assays, 83 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 31 83 5.3
Toxicity — 8 assays, 13 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 8 13 5.5

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine