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Target Snapshot

CHEMBL6142 Target Snapshot

Protein mono-ADP-ribosyltransferase PARP4 · SINGLE PROTEIN · Homo sapiens

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58Compounds
21Assays
7Approved Drugs
68.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt Q9UKK3. Use UniProt Q9UKK3 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q9UKK3 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Protein mono-ADP-ribosyltransferase PARP4 as ChEMBL target CHEMBL6142, mapped to UniProt Q9UKK3. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Protein mono-ADP-ribosyltransferase PARP4
SINGLE PROTEIN · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL6142
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
Q9UKK3
Protein mono-ADP-ribosyltransferase PARP4
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Protein mono-ADP-ribosyltransferase PARP4 is the right protein anchor across sources, using UniProt Q9UKK3 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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Preferred NameProtein mono-ADP-ribosyltransferase PARP4
Target TypeSINGLE PROTEIN
OrganismHomo sapiens
UniProtQ9UKK3
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelProtein mono-ADP-ribosyltransferase PARP4
UniProt AccessionQ9UKK3
Component TypeProtein
Sequence Length1724 aa

Protein mono-ADP-ribosyltransferase PARP4

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Protein mono-ADP-ribosyltransferase PARP4, mapped to UniProt Q9UKK3. Sequence length is 1724 aa.

Mapped IDQ9UKK3
Review nameProtein mono-ADP-ribosyltransferase PARP4
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

7
Approved
2
Phase III
1
Phase I
Assay Mix

Activity Type Distribution

IC5063.0
KD5.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL3137320 9.15 Kd 0.7 Approved
CHEMBL5402698 9.0 IC50 1.0 Preclinical
CHEMBL521686 7.87 IC50 13.5 Approved
CHEMBL506871 6.98 Kd 105.0 Clinical
CHEMBL521686 6.85 Kd 141.0 Approved
CHEMBL3764816 6.59 IC50 254.0 Preclinical
CHEMBL1094636 6.57 Kd 272.0 Approved
CHEMBL1094636 6.48 IC50 330.0 Approved
CHEMBL595018 6.36 IC50 440.0 Preclinical
CHEMBL1173055 6.3 Kd 503.0 Approved
Distribution

pChEMBL Value Distribution

7
5.0
2
5.5
14
6.0
5
6.5
0
7.0
1
7.5
0
8.0
0
8.5
2
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

TALAZOPARIB
CHEMBL3137320
Approved 2018
Properties Compare Identifier
NIRAPARIB
CHEMBL1094636
Approved 2017
Properties Compare Identifier
RUCAPARIB
CHEMBL1173055
Approved 2016
Properties Compare Identifier
OLAPARIB
CHEMBL521686
Approved 2014
Properties Compare Identifier
Assay Landscape

Assay Landscape

21
Total Assays
30
Tested Compounds
1
Assay Types
Binding — 21 assays, 30 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 14 13 6.0
assay format 7 17 5.8

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine