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Target Snapshot

CHEMBL614227 Target Snapshot

WEHI-164 · CELL-LINE · Mus musculus

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91Compounds
18Assays
1Approved Drugs
105.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats WEHI-164 as ChEMBL target CHEMBL614227. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
WEHI-164
CELL-LINE · Mus musculus
As of 2026-09-14
ChEMBL target ID
CHEMBL614227
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether WEHI-164 still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameWEHI-164
Target TypeCELL-LINE
OrganismMus musculus
ChEMBL ↗

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelWEHI-164
UniProt AccessionN/A

WEHI-164

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as WEHI-164.

Review nameWEHI-164
OrganismMus musculus
Clinical Profile

Clinical Phase Distribution

1
Approved
Assay Mix

Activity Type Distribution

IC50105.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL1425 7.82 IC50 15.0 Approved
CHEMBL213497 7.52 IC50 30.0 Preclinical
CHEMBL509315 7.1 IC50 80.0 Preclinical
CHEMBL508996 7.0 IC50 100.0 Preclinical
CHEMBL507615 6.85 IC50 140.0 Preclinical
CHEMBL505847 6.62 IC50 240.0 Preclinical
CHEMBL508736 6.58 IC50 260.0 Preclinical
CHEMBL486881 6.47 IC50 340.0 Preclinical
CHEMBL413915 6.44 IC50 360.0 Preclinical
CHEMBL503852 6.42 IC50 380.0 Preclinical
Distribution

pChEMBL Value Distribution

8
5.0
5
5.5
15
6.0
3
6.5
2
7.0
5
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

MERCAPTOPURINE ANHYDROUS
CHEMBL1425
Approved 1953
Properties Compare Identifier
Assay Landscape

Assay Landscape

18
Total Assays
32
Tested Compounds
1
Assay Types
Functional — 18 assays, 32 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 18 32 6.2

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine