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Target Snapshot

CHEMBL614241 Target Snapshot

PSN1 · CELL-LINE · Homo sapiens

318Compounds
52Assays
34Approved Drugs
308.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats PSN1 as ChEMBL target CHEMBL614241. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
PSN1
CELL-LINE · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL614241
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether PSN1 still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

Jump to Disease Context
Need a meeting-ready explanation of why this target matters?
Evidence Card
Review-ready rationale with source-aware context

Open the one-page evidence card when you want the rationale, activity base, and attribution together.

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelPSN1
UniProt AccessionN/A

PSN1

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as PSN1.

Review namePSN1
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

34
Approved
13
Phase III
13
Phase II
7
Phase I
Assay Mix

Activity Type Distribution

IC50296.0
EC5012.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL888 10.78 IC50 0.01652 Approved
CHEMBL96926 10.17 IC50 0.06693 Preclinical
CHEMBL94657 9.76 IC50 0.1731 Clinical
CHEMBL3545252 9.23 IC50 0.5815 Approved
CHEMBL4764390 9.0 IC50 1.0 Preclinical
CHEMBL325041 8.99 IC50 1.011 Clinical
CHEMBL159 8.9 IC50 1.248 Approved
CHEMBL428647 8.89 IC50 1.301 Approved
CHEMBL52073 8.7 EC50 2.0 Preclinical
CHEMBL2022975 8.7 IC50 2.0 Preclinical
Distribution

pChEMBL Value Distribution

32
5.0
42
5.5
12
6.0
9
6.5
12
7.0
7
7.5
7
8.0
8
8.5
2
9.0
1
9.5
pChEMBL
Approved Drugs

Approved Drugs

SELUMETINIB
CHEMBL1614701
Approved 2020
TEMSIROLIMUS
CHEMBL1201182
Approved 2007
DASATINIB
CHEMBL5416410
Approved 2006
MYCOPHENOLIC ACID
CHEMBL866
Approved 2004
SIROLIMUS
CHEMBL413
Approved 1999
GEMCITABINE
CHEMBL888
Approved 1996
DOCETAXEL
CHEMBL3545252
Approved 1995
PACLITAXEL
CHEMBL428647
Approved 1992
MITOMYCIN
CHEMBL105
Approved 1981
DOXORUBICIN
CHEMBL53463
Approved 1974
CYTARABINE
CHEMBL803
Approved 1969
VINBLASTINE
CHEMBL159
Approved 1965
Assay Landscape

Assay Landscape

52
Total Assays
196
Tested Compounds
2
Assay Types
Functional — 49 assays, 196 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 49 196 5.7
ADME — 3 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 3 0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine