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Target Snapshot

CHEMBL614243 Target Snapshot

SW1088 · CELL-LINE · Homo sapiens

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138Compounds
12Assays
20Approved Drugs
124.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats SW1088 as ChEMBL target CHEMBL614243. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
SW1088
CELL-LINE · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL614243
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether SW1088 still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameSW1088
Target TypeCELL-LINE
OrganismHomo sapiens
ChEMBL ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelSW1088
UniProt AccessionN/A

SW1088

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as SW1088.

Review nameSW1088
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

20
Approved
9
Phase III
10
Phase II
3
Phase I
Assay Mix

Activity Type Distribution

IC50124.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL3545252 8.53 IC50 2.948 Approved
CHEMBL94657 8.24 IC50 5.791 Clinical
CHEMBL119700 8.1 IC50 8.0 Preclinical
CHEMBL159 7.77 IC50 16.97 Approved
CHEMBL65 7.56 IC50 27.77 Preclinical
CHEMBL1879463 7.55 IC50 28.29 Clinical
CHEMBL1201182 7.5 IC50 31.84 Approved
CHEMBL449158 7.35 IC50 44.9 Clinical
CHEMBL117427 7.1 IC50 80.0 Preclinical
CHEMBL553025 7.1 IC50 79.44 Approved
Distribution

pChEMBL Value Distribution

22
5.0
16
5.5
10
6.0
2
6.5
4
7.0
4
7.5
2
8.0
1
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

MIDOSTAURIN
CHEMBL608533
Approved 2017
Properties Compare Identifier
PONATINIB
CHEMBL1171837
Approved 2012
Properties Compare Identifier
TEMSIROLIMUS
CHEMBL1201182
Approved 2007
Properties Compare Identifier
DOCETAXEL
CHEMBL3545252
Approved 1995
Properties Compare Identifier
VINORELBINE
CHEMBL553025
Approved 1994
Properties Compare Identifier
VINBLASTINE
CHEMBL159
Approved 1965
Properties Compare Identifier
Assay Landscape

Assay Landscape

12
Total Assays
114
Tested Compounds
1
Assay Types
Functional — 12 assays, 114 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 12 114 5.6

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine