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Target Snapshot

CHEMBL614247 Target Snapshot

U-87 MG · CELL-LINE · Homo sapiens

3,156Compounds
1,536Assays
49Approved Drugs
2,651.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats U-87 MG as ChEMBL target CHEMBL614247. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
U-87 MG
CELL-LINE · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL614247
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether U-87 MG still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelU-87 MG
UniProt AccessionN/A

U-87 MG

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as U-87 MG.

Review nameU-87 MG
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

49
Approved
17
Phase III
30
Phase II
6
Phase I
Assay Mix

Activity Type Distribution

IC502,557.0
EC5094.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL5428624 10.4 IC50 0.04 Preclinical
CHEMBL1098108 10.24 IC50 0.057 Preclinical
CHEMBL5397139 10.1 IC50 0.08 Preclinical
CHEMBL337820 10.0 IC50 0.1 Preclinical
CHEMBL1096754 9.77 IC50 0.17 Preclinical
CHEMBL105821 9.7 IC50 0.2 Preclinical
CHEMBL113436 9.7 IC50 0.2 Preclinical
CHEMBL2103835 9.7 EC50 0.2 Preclinical
CHEMBL4159373 9.7 IC50 0.2 Preclinical
CHEMBL140827 9.52 IC50 0.3 Preclinical
Distribution

pChEMBL Value Distribution

436
5.0
345
5.5
217
6.0
97
6.5
107
7.0
57
7.5
44
8.0
29
8.5
26
9.0
7
9.5
pChEMBL
Approved Drugs

Approved Drugs

IVOSIDENIB
CHEMBL3989958
Approved 2018
ABEMACICLIB
CHEMBL3301610
Approved 2017
PALBOCICLIB
CHEMBL189963
Approved 2015
GEMCITABINE
CHEMBL888
Approved 1996
TOPOTECAN
CHEMBL84
Approved 1996
DOCETAXEL
CHEMBL3545252
Approved 1995
VINORELBINE
CHEMBL553025
Approved 1994
TRIMETREXATE
CHEMBL119
Approved 1993
PACLITAXEL
CHEMBL428647
Approved 1992
NICLOSAMIDE
CHEMBL1448
Approved 1982
DAUNORUBICIN
CHEMBL178
Approved 1979
DOXORUBICIN
CHEMBL53463
Approved 1974
DOXORUBICIN HYDROCHLORIDE
CHEMBL359744
Approved 1974
CYTARABINE
CHEMBL803
Approved 1969
VINBLASTINE
CHEMBL159
Approved 1965
COLCHICINE
CHEMBL107
Approved 1961
METHOTREXATE
CHEMBL34259
Approved 1953
Assay Landscape

Assay Landscape

1,536
Total Assays
1,860
Tested Compounds
3
Assay Types
Functional — 1,501 assays, 1,860 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 1,324 1,860 5.7
organism-based format 175 0
cell membrane format 2 0
ADME — 31 assays, 13 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 31 13 5.5
Toxicity — 4 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 4 0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine