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Target Snapshot

CHEMBL614257 Target Snapshot

COLO 320 · CELL-LINE · Homo sapiens

230Compounds
66Assays
2Approved Drugs
188.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats COLO 320 as ChEMBL target CHEMBL614257. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
COLO 320
CELL-LINE · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL614257
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether COLO 320 still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelCOLO 320
UniProt AccessionN/A

COLO 320

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as COLO 320.

Review nameCOLO 320
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

2
Approved
1
Phase III
1
Phase II
Assay Mix

Activity Type Distribution

IC50175.0
EC5013.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL803 7.4 IC50 40.0 Approved
CHEMBL369474 7.16 IC50 69.0 Preclinical
CHEMBL1738758 6.72 IC50 192.0 Clinical
CHEMBL142678 6.7 EC50 200.0 Preclinical
CHEMBL3122195 6.46 IC50 350.0 Preclinical
CHEMBL3122193 6.26 IC50 550.0 Preclinical
CHEMBL189987 6.05 IC50 900.0 Preclinical
CHEMBL3122194 6.02 IC50 960.0 Preclinical
CHEMBL38761 5.92 IC50 1200.0 Preclinical
CHEMBL1236095 5.89 IC50 1284.0 Preclinical
Distribution

pChEMBL Value Distribution

7
5.0
7
5.5
4
6.0
2
6.5
2
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

CYTARABINE
CHEMBL803
Approved 1969
Assay Landscape

Assay Landscape

67
Total Assays
84
Tested Compounds
2
Assay Types
Functional — 65 assays, 84 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 62 84 4.8
organism-based format 3 0
ADME — 2 assays, 16 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 2 16 4.2

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine