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Target Snapshot

CHEMBL614268 Target Snapshot

AG1523 · CELL-LINE · Homo sapiens

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116Compounds
11Assays
1Approved Drugs
117.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats AG1523 as ChEMBL target CHEMBL614268. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
AG1523
CELL-LINE · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL614268
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether AG1523 still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

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Evidence Card
Review-ready rationale with source-aware context

Open the one-page evidence card when you want the rationale, activity base, and attribution together.

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameAG1523
Target TypeCELL-LINE
OrganismHomo sapiens
ChEMBL ↗

Next Actions

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelAG1523
UniProt AccessionN/A

AG1523

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as AG1523.

Review nameAG1523
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

1
Approved
Assay Mix

Activity Type Distribution

IC50116.0
EC501.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL326961 7.2 IC50 63.0 Preclinical
CHEMBL345525 7.07 IC50 85.0 Preclinical
CHEMBL116582 6.69 IC50 205.0 Preclinical
CHEMBL326828 6.59 IC50 255.0 Preclinical
CHEMBL411432 6.54 IC50 285.0 Preclinical
CHEMBL323813 6.48 IC50 330.0 Preclinical
CHEMBL273619 6.46 IC50 345.0 Preclinical
CHEMBL116934 6.42 IC50 385.0 Preclinical
CHEMBL358102 6.42 IC50 385.0 Preclinical
CHEMBL346184 6.4 IC50 400.0 Preclinical
Distribution

pChEMBL Value Distribution

4
5.0
5
5.5
17
6.0
3
6.5
2
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

DOXORUBICIN HYDROCHLORIDE
CHEMBL359744
Approved 1974
Properties Compare Identifier
Assay Landscape

Assay Landscape

11
Total Assays
25
Tested Compounds
3
Assay Types
Functional — 9 assays, 25 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 9 25 6.2
ADME — 1 assays, 10 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 1 10 5.3
Toxicity — 1 assays, 6 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 1 6 4.5

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine