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Target Snapshot

CHEMBL614280 Target Snapshot

BEL-7404 tumor cell line · CELL-LINE · Homo sapiens

Back to Search Search this target Browse approvals Evidence Card
95Compounds
79Assays
4Approved Drugs
89.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats BEL-7404 tumor cell line as ChEMBL target CHEMBL614280. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
BEL-7404 tumor cell line
CELL-LINE · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL614280
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether BEL-7404 tumor cell line still has a stable protein naming contract across sources.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameBEL-7404 tumor cell line
Target TypeCELL-LINE
OrganismHomo sapiens
ChEMBL ↗

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SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelBEL-7404 tumor cell line
UniProt AccessionN/A

BEL-7404 tumor cell line

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as BEL-7404 tumor cell line.

Review nameBEL-7404 tumor cell line
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

4
Approved
1
Phase III
Assay Mix

Activity Type Distribution

IC5089.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL3356793 8.68 IC50 2.1 Preclinical
CHEMBL4089402 7.86 IC50 13.75 Preclinical
CHEMBL325041 7.6 IC50 25.04 Clinical
CHEMBL443535 7.5 IC50 32.0 Preclinical
CHEMBL4095083 7.37 IC50 42.23 Preclinical
CHEMBL4100727 7.33 IC50 47.26 Preclinical
CHEMBL327536 7.2 IC50 63.0 Preclinical
CHEMBL262508 7.0 IC50 100.0 Preclinical
CHEMBL4537640 7.0 IC50 100.0 Preclinical
CHEMBL53463 6.89 IC50 130.0 Approved
Distribution

pChEMBL Value Distribution

13
5.0
4
5.5
2
6.0
2
6.5
5
7.0
3
7.5
0
8.0
1
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

DOXORUBICIN
CHEMBL53463
Approved 1974
Properties Compare Identifier
Assay Landscape

Assay Landscape

84
Total Assays
66
Tested Compounds
1
Assay Types
Functional — 84 assays, 66 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 52 66 5.2
organism-based format 32 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine