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Target Snapshot

CHEMBL614285 Target Snapshot

DLD-1 · CELL-LINE · Homo sapiens

15,630Compounds
659Assays
28Approved Drugs
2,037.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats DLD-1 as ChEMBL target CHEMBL614285. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
DLD-1
CELL-LINE · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL614285
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether DLD-1 still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

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Evidence Card
Review-ready rationale with source-aware context

Open the one-page evidence card when you want the rationale, activity base, and attribution together.

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelDLD-1
UniProt AccessionN/A

DLD-1

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as DLD-1.

Review nameDLD-1
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

28
Approved
10
Phase III
11
Phase II
5
Phase I
Assay Mix

Activity Type Distribution

IC501,794.0
EC50243.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL4544901 10.52 IC50 0.03 Preclinical
CHEMBL4593271 10.0 IC50 0.1 Preclinical
CHEMBL1683602 9.77 IC50 0.17 Preclinical
CHEMBL4448361 9.7 IC50 0.2 Preclinical
CHEMBL1683528 9.7 IC50 0.2 Preclinical
CHEMBL1683550 9.66 IC50 0.22 Preclinical
CHEMBL1683601 9.64 IC50 0.23 Preclinical
CHEMBL1683596 9.64 IC50 0.23 Preclinical
CHEMBL1683554 9.64 IC50 0.23 Preclinical
CHEMBL1683546 9.64 IC50 0.23 Preclinical
Distribution

pChEMBL Value Distribution

306
5.0
194
5.5
142
6.0
126
6.5
114
7.0
70
7.5
58
8.0
56
8.5
55
9.0
16
9.5
pChEMBL
Approved Drugs

Approved Drugs

TALAZOPARIB
CHEMBL3137320
Approved 2018
NIRAPARIB
CHEMBL1094636
Approved 2017
RUCAPARIB
CHEMBL1173055
Approved 2016
OLAPARIB
CHEMBL521686
Approved 2014
ERIBULIN
CHEMBL1683590
Approved 2010
VORINOSTAT
CHEMBL98
Approved 2006
PACLITAXEL
CHEMBL428647
Approved 1992
PODOFILOX
CHEMBL61
Approved 1990
AMSACRINE
CHEMBL43
Approved 1987
ETOPOSIDE
CHEMBL44657
Approved 1983
DOXORUBICIN
CHEMBL53463
Approved 1974
FLOXURIDINE
CHEMBL917
Approved 1970
VINBLASTINE
CHEMBL159
Approved 1965
COLCHICINE
CHEMBL107
Approved 1961
Assay Landscape

Assay Landscape

661
Total Assays
1,366
Tested Compounds
4
Assay Types
Functional — 642 assays, 1,366 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 590 1,366 6.1
organism-based format 52 0
ADME — 15 assays, 15 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 15 15 5.0
Toxicity — 3 assays, 1 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 3 1 5.1
Unassigned — 1 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 1 0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine