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Target Snapshot

CHEMBL614286 Target Snapshot

DMS-79 · CELL-LINE · Homo sapiens

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123Compounds
19Assays
20Approved Drugs
124.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats DMS-79 as ChEMBL target CHEMBL614286. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
DMS-79
CELL-LINE · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL614286
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether DMS-79 still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameDMS-79
Target TypeCELL-LINE
OrganismHomo sapiens
ChEMBL ↗

Next Actions

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelDMS-79
UniProt AccessionN/A

DMS-79

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as DMS-79.

Review nameDMS-79
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

20
Approved
5
Phase III
7
Phase II
1
Phase I
Assay Mix

Activity Type Distribution

IC50121.0
EC503.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL4175749 8.85 IC50 1.43 Preclinical
CHEMBL4160638 8.72 IC50 1.92 Preclinical
CHEMBL4165141 8.72 IC50 1.91 Preclinical
CHEMBL4167069 8.64 IC50 2.31 Preclinical
CHEMBL4161710 8.62 IC50 2.37 Preclinical
CHEMBL4172341 8.41 IC50 3.88 Preclinical
CHEMBL4168560 8.39 IC50 4.03 Preclinical
CHEMBL4164039 8.36 IC50 4.37 Preclinical
CHEMBL4171911 7.64 IC50 23.0 Preclinical
CHEMBL61 7.64 IC50 23.0 Approved
Distribution

pChEMBL Value Distribution

7
5.0
11
5.5
9
6.0
1
6.5
2
7.0
3
7.5
3
8.0
5
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

DOCETAXEL
CHEMBL3545252
Approved 1995
Properties Compare Identifier
VINORELBINE
CHEMBL553025
Approved 1994
Properties Compare Identifier
PODOFILOX
CHEMBL61
Approved 1990
Properties Compare Identifier
VINBLASTINE
CHEMBL159
Approved 1965
Properties Compare Identifier
METHOTREXATE
CHEMBL34259
Approved 1953
Properties Compare Identifier
Assay Landscape

Assay Landscape

19
Total Assays
118
Tested Compounds
1
Assay Types
Functional — 19 assays, 118 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 19 118 5.9

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine