Skip to main content
Free research Free research Free target review with research home and workspace preview
Quick search ChEMBL 36
Loading Target Snapshot...
Querying ChEMBL database. This may take a few seconds.
Target Snapshot

CHEMBL614309 Target Snapshot

T-cell · CELL-LINE

1,449Compounds
397Assays
13Approved Drugs
1,183.0Activities
Free Research Context

Research home keeps recent targets

This target will appear in recent viewed items on this browser. Use the demo workspace to preview watch rules and decision queues.

Navigation

Switch target

Move to another high-traffic target or paste a specific ChEMBL target ID.

Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats T-cell as ChEMBL target CHEMBL614309. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
T-cell
CELL-LINE
As of 2026-09-13
ChEMBL target ID
CHEMBL614309
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether T-cell still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

Jump to Disease Context
Need a meeting-ready explanation of why this target matters?
Evidence Card
Review-ready rationale with source-aware context

Open the one-page evidence card when you want the rationale, activity base, and attribution together.

Open Review-ready Card
Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelT-cell
UniProt AccessionN/A

T-cell

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as T-cell.

Review nameT-cell
Clinical Profile

Clinical Phase Distribution

13
Approved
3
Phase III
1
Phase II
Assay Mix

Activity Type Distribution

IC501,067.0
EC50116.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL846 10.3 IC50 0.05 Approved
CHEMBL212689 9.92 IC50 0.12 Preclinical
CHEMBL412818 9.74 IC50 0.18 Preclinical
CHEMBL269732 9.74 IC50 0.18 Approved
CHEMBL266443 9.7 IC50 0.2 Preclinical
CHEMBL68027 9.7 IC50 0.2 Preclinical
CHEMBL431360 9.7 IC50 0.2 Preclinical
CHEMBL419817 9.7 IC50 0.2 Preclinical
CHEMBL437410 9.49 IC50 0.32 Preclinical
CHEMBL440434 9.47 IC50 0.34 Preclinical
Distribution

pChEMBL Value Distribution

119
5.0
144
5.5
119
6.0
100
6.5
68
7.0
56
7.5
53
8.0
37
8.5
29
9.0
8
9.5
pChEMBL
Approved Drugs

Approved Drugs

POMALIDOMIDE
CHEMBL43452
Approved 2013
TOFACITINIB
CHEMBL221959
Approved 2012
DASATINIB
CHEMBL5416410
Approved 2006
LENALIDOMIDE
CHEMBL848
Approved 2005
MYCOPHENOLIC ACID
CHEMBL866
Approved 2004
SIROLIMUS
CHEMBL413
Approved 1999
TACROLIMUS ANHYDROUS
CHEMBL269732
Approved 1994
CYCLOSPORINE
CHEMBL160
Approved 1983
CALCITRIOL
CHEMBL846
Approved 1978
DEXAMETHASONE
CHEMBL384467
Approved 1958
Assay Landscape

Assay Landscape

397
Total Assays
733
Tested Compounds
3
Assay Types
Functional — 368 assays, 733 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 357 712 6.5
assay format 5 20 5.9
tissue-based format 4 1 7.5
organism-based format 2 0
ADME — 20 assays, 1 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 19 1 8.2
assay format 1 0
Toxicity — 9 assays, 9 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 8 9 4.8
assay format 1 0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine