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Target Snapshot

CHEMBL614332 Target Snapshot

MCR · CELL-LINE · Anura

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36Compounds
3Assays
1Approved Drugs
35.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats MCR as ChEMBL target CHEMBL614332. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
MCR
CELL-LINE · Anura
As of 2026-09-14
ChEMBL target ID
CHEMBL614332
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether MCR still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

Jump to Disease Context
Need a meeting-ready explanation of why this target matters?
Evidence Card
Review-ready rationale with source-aware context

Open the one-page evidence card when you want the rationale, activity base, and attribution together.

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameMCR
Target TypeCELL-LINE
OrganismAnura
ChEMBL ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelMCR
UniProt AccessionN/A

MCR

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as MCR.

Review nameMCR
OrganismAnura
Clinical Profile

Clinical Phase Distribution

1
Approved
Assay Mix

Activity Type Distribution

IC5022.0
EC5013.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL441738 10.82 EC50 0.015 Approved
CHEMBL263948 9.82 EC50 0.15 Preclinical
CHEMBL264190 6.7 EC50 200.0 Preclinical
CHEMBL65339 5.82 EC50 1500.0 Preclinical
CHEMBL3350355 5.72 EC50 1900.0 Preclinical
CHEMBL302703 5.7 EC50 2000.0 Preclinical
CHEMBL419625 5.38 EC50 4200.0 Preclinical
CHEMBL302782 5.26 EC50 5500.0 Preclinical
CHEMBL2114996 5.0 EC50 10000.0 Preclinical
CHEMBL3288099 4.73 IC50 18500.0 Preclinical
Distribution

pChEMBL Value Distribution

3
5.0
3
5.5
0
6.0
1
6.5
0
7.0
0
7.5
0
8.0
0
8.5
0
9.0
1
9.5
pChEMBL
Approved Drugs

Approved Drugs

AFAMELANOTIDE
CHEMBL441738
Approved 2014
Properties Compare Identifier
Assay Landscape

Assay Landscape

3
Total Assays
10
Tested Compounds
2
Assay Types
Functional — 2 assays, 10 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 2 10 6.5
ADME — 1 assays, 1 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 1 1 4.7

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine