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Target Snapshot

CHEMBL614343 Target Snapshot

MES-SA · CELL-LINE · Homo sapiens

Back to Search Search this target Browse approvals Evidence Card
602Compounds
133Assays
16Approved Drugs
659.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats MES-SA as ChEMBL target CHEMBL614343. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
MES-SA
CELL-LINE · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL614343
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether MES-SA still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

Jump to Disease Context
Need a meeting-ready explanation of why this target matters?
Evidence Card
Review-ready rationale with source-aware context

Open the one-page evidence card when you want the rationale, activity base, and attribution together.

Open Review-ready Card
Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameMES-SA
Target TypeCELL-LINE
OrganismHomo sapiens
ChEMBL ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelMES-SA
UniProt AccessionN/A

MES-SA

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as MES-SA.

Review nameMES-SA
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

16
Approved
5
Phase III
10
Phase II
2
Phase I
Assay Mix

Activity Type Distribution

IC50646.0
EC5013.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL4797377 10.94 EC50 0.0116 Preclinical
CHEMBL96926 10.57 IC50 0.02681 Preclinical
CHEMBL4784749 10.47 EC50 0.034 Preclinical
CHEMBL5182623 10.4 IC50 0.04 Preclinical
CHEMBL4796838 10.34 EC50 0.046 Preclinical
CHEMBL4795022 10.33 EC50 0.047 Preclinical
CHEMBL4756044 10.15 EC50 0.07 Preclinical
CHEMBL5192239 10.14 IC50 0.072 Preclinical
CHEMBL2103835 10.02 IC50 0.096 Preclinical
CHEMBL5206108 9.89 IC50 0.13 Preclinical
Distribution

pChEMBL Value Distribution

145
5.0
93
5.5
47
6.0
28
6.5
21
7.0
22
7.5
19
8.0
20
8.5
15
9.0
2
9.5
pChEMBL
Approved Drugs

Approved Drugs

MIDOSTAURIN
CHEMBL608533
Approved 2017
Properties Compare Identifier
PONATINIB
CHEMBL1171837
Approved 2012
Properties Compare Identifier
GEMCITABINE
CHEMBL888
Approved 1996
Properties Compare Identifier
DOCETAXEL ANHYDROUS
CHEMBL92
Approved 1995
Properties Compare Identifier
VINORELBINE
CHEMBL553025
Approved 1994
Properties Compare Identifier
PACLITAXEL
CHEMBL428647
Approved 1992
Properties Compare Identifier
MITOXANTRONE
CHEMBL58
Approved 1987
Properties Compare Identifier
ETOPOSIDE
CHEMBL44657
Approved 1983
Properties Compare Identifier
MITOMYCIN
CHEMBL105
Approved 1981
Properties Compare Identifier
DAUNORUBICIN
CHEMBL178
Approved 1979
Properties Compare Identifier
DOXORUBICIN
CHEMBL53463
Approved 1974
Properties Compare Identifier
VINCRISTINE
CHEMBL90555
Approved 1963
Properties Compare Identifier
COLCHICINE
CHEMBL107
Approved 1961
Properties Compare Identifier
Assay Landscape

Assay Landscape

133
Total Assays
371
Tested Compounds
1
Assay Types
Functional — 133 assays, 371 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 133 371 5.9

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine