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Target Snapshot

CHEMBL614348 Target Snapshot

NCI-H1975 · CELL-LINE · Homo sapiens

3,951Compounds
1,738Assays
41Approved Drugs
3,637.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats NCI-H1975 as ChEMBL target CHEMBL614348. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
NCI-H1975
CELL-LINE · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL614348
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether NCI-H1975 still has a stable protein naming contract across sources.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelNCI-H1975
UniProt AccessionN/A

NCI-H1975

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as NCI-H1975.

Review nameNCI-H1975
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

41
Approved
14
Phase III
15
Phase II
5
Phase I
Assay Mix

Activity Type Distribution

IC503,539.0
EC5098.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL3353410 10.96 IC50 0.011 Approved
CHEMBL5590430 10.89 IC50 0.013 Preclinical
CHEMBL4793880 10.68 IC50 0.021 Preclinical
CHEMBL5592293 10.62 IC50 0.024 Preclinical
CHEMBL5584148 10.59 IC50 0.026 Preclinical
CHEMBL5593035 10.46 IC50 0.035 Preclinical
CHEMBL5592071 10.38 IC50 0.042 Preclinical
CHEMBL5594458 10.36 IC50 0.044 Preclinical
CHEMBL5594833 10.2 IC50 0.063 Preclinical
CHEMBL5595676 10.14 IC50 0.072 Preclinical
Distribution

pChEMBL Value Distribution

635
5.0
554
5.5
347
6.0
283
6.5
219
7.0
122
7.5
55
8.0
53
8.5
18
9.0
17
9.5
pChEMBL
Approved Drugs

Approved Drugs

DACOMITINIB ANHYDROUS
CHEMBL2110732
Approved 2018
NERATINIB
CHEMBL180022
Approved 2017
ABEMACICLIB
CHEMBL3301610
Approved 2017
BRIGATINIB
CHEMBL3545311
Approved 2017
OLMUTINIB
CHEMBL3786343
Approved 2016
PANOBINOSTAT
CHEMBL483254
Approved 2015
OSIMERTINIB
CHEMBL3353410
Approved 2015
AFATINIB
CHEMBL1173655
Approved 2013
IBRUTINIB
CHEMBL1873475
Approved 2013
OMACETAXINE MEPESUCCINATE
CHEMBL46286
Approved 2009
DASATINIB
CHEMBL5416410
Approved 2006
VINORELBINE
CHEMBL553025
Approved 1994
PACLITAXEL
CHEMBL428647
Approved 1992
ETOPOSIDE
CHEMBL44657
Approved 1983
DAUNORUBICIN
CHEMBL178
Approved 1979
DOXORUBICIN
CHEMBL53463
Approved 1974
DOXORUBICIN HYDROCHLORIDE
CHEMBL359744
Approved 1974
VINBLASTINE
CHEMBL159
Approved 1965
Assay Landscape

Assay Landscape

1,738
Total Assays
2,616
Tested Compounds
4
Assay Types
Functional — 1,711 assays, 2,616 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 1,501 2,616 5.9
organism-based format 210 0
ADME — 17 assays, 16 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 17 16 4.2
Unassigned — 7 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 7 0
Toxicity — 3 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
organism-based format 3 0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine