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Target Snapshot

CHEMBL614350 Target Snapshot

MH60 · CELL-LINE · Mus musculus

50Compounds
8Assays
1Approved Drugs
86.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats MH60 as ChEMBL target CHEMBL614350. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
MH60
CELL-LINE · Mus musculus
As of 2026-09-14
ChEMBL target ID
CHEMBL614350
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether MH60 still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelMH60
UniProt AccessionN/A

MH60

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as MH60.

Review nameMH60
OrganismMus musculus
Clinical Profile

Clinical Phase Distribution

1
Approved
1
Phase II
Assay Mix

Activity Type Distribution

IC5086.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL486200 5.89 IC50 1300.0 Preclinical
CHEMBL486613 5.7 IC50 2000.0 Preclinical
CHEMBL451719 5.62 IC50 2400.0 Preclinical
CHEMBL46740 5.42 IC50 3800.0 Approved
CHEMBL486201 5.37 IC50 4300.0 Preclinical
CHEMBL487004 5.28 IC50 5300.0 Preclinical
CHEMBL455362 5.25 IC50 5600.0 Preclinical
CHEMBL454990 5.19 IC50 6400.0 Preclinical
CHEMBL452684 5.17 IC50 6800.0 Preclinical
CHEMBL5423704 5.12 IC50 7500.0 Preclinical
Distribution

pChEMBL Value Distribution

14
5.0
3
5.5
0
6.0
0
6.5
0
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

8
Total Assays
24
Tested Compounds
1
Assay Types
Functional — 8 assays, 24 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 8 24 5.0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine