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Target Snapshot

CHEMBL614353 Target Snapshot

MKN-28 · CELL-LINE · Homo sapiens

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351Compounds
127Assays
25Approved Drugs
236.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats MKN-28 as ChEMBL target CHEMBL614353. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
MKN-28
CELL-LINE · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL614353
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether MKN-28 still has a stable protein naming contract across sources.

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Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameMKN-28
Target TypeCELL-LINE
OrganismHomo sapiens
ChEMBL ↗

Next Actions

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelMKN-28
UniProt AccessionN/A

MKN-28

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as MKN-28.

Review nameMKN-28
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

25
Approved
10
Phase III
11
Phase II
6
Phase I
Assay Mix

Activity Type Distribution

IC50236.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL3358841 10.4 IC50 0.04 Preclinical
CHEMBL94657 9.34 IC50 0.4616 Clinical
CHEMBL159 8.57 IC50 2.698 Approved
CHEMBL3545252 8.5 IC50 3.172 Approved
CHEMBL553025 8.32 IC50 4.771 Approved
CHEMBL318896 8.06 IC50 8.8 Preclinical
CHEMBL96926 8.01 IC50 9.79 Preclinical
CHEMBL1972860 7.85 IC50 13.98 Clinical
CHEMBL54918 7.55 IC50 28.0 Clinical
CHEMBL252164 7.52 IC50 30.12 Clinical
Distribution

pChEMBL Value Distribution

36
5.0
34
5.5
12
6.0
10
6.5
4
7.0
4
7.5
3
8.0
2
8.5
1
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

TEMSIROLIMUS
CHEMBL1201182
Approved 2007
Properties Compare Identifier
DOCETAXEL
CHEMBL3545252
Approved 1995
Properties Compare Identifier
VINORELBINE
CHEMBL553025
Approved 1994
Properties Compare Identifier
MITOMYCIN
CHEMBL105
Approved 1981
Properties Compare Identifier
DOXORUBICIN
CHEMBL53463
Approved 1974
Properties Compare Identifier
FLOXURIDINE
CHEMBL917
Approved 1970
Properties Compare Identifier
VINBLASTINE
CHEMBL159
Approved 1965
Properties Compare Identifier
Assay Landscape

Assay Landscape

127
Total Assays
188
Tested Compounds
3
Assay Types
Functional — 125 assays, 188 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 86 188 5.5
organism-based format 39 0 —
ADME — 1 assays, 2 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 1 2 4.7
Toxicity — 1 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 1 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine