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Target Snapshot

CHEMBL614357 Target Snapshot

Beta-TC6 · CELL-LINE · Mus musculus

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451Compounds
31Assays
2Approved Drugs
98.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Beta-TC6 as ChEMBL target CHEMBL614357. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Beta-TC6
CELL-LINE · Mus musculus
As of 2026-09-14
ChEMBL target ID
CHEMBL614357
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Beta-TC6 still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

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Evidence Card
Review-ready rationale with source-aware context

Open the one-page evidence card when you want the rationale, activity base, and attribution together.

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameBeta-TC6
Target TypeCELL-LINE
OrganismMus musculus
ChEMBL ↗

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelBeta-TC6
UniProt AccessionN/A

Beta-TC6

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Beta-TC6.

Review nameBeta-TC6
OrganismMus musculus
Clinical Profile

Clinical Phase Distribution

2
Approved
2
Phase II
Assay Mix

Activity Type Distribution

IC5078.0
EC5020.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL134168 7.7 EC50 20.0 Preclinical
CHEMBL134168 7.7 IC50 20.0 Preclinical
CHEMBL341410 7.7 IC50 20.0 Preclinical
CHEMBL135091 7.52 IC50 30.0 Preclinical
CHEMBL336621 7.16 IC50 70.0 Preclinical
CHEMBL135191 6.82 IC50 150.0 Clinical
CHEMBL135240 6.82 IC50 150.0 Preclinical
CHEMBL445321 6.82 EC50 150.0 Preclinical
CHEMBL134220 6.8 IC50 160.0 Preclinical
CHEMBL136005 6.77 IC50 170.0 Preclinical
Distribution

pChEMBL Value Distribution

17
5.0
15
5.5
10
6.0
16
6.5
1
7.0
4
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

31
Total Assays
77
Tested Compounds
3
Assay Types
Functional — 29 assays, 77 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 29 77 5.7
ADME — 1 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 1 0 —
Toxicity — 1 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 1 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine