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Target Snapshot

CHEMBL614358 Target Snapshot

BJ · CELL-LINE · Homo sapiens

3,966Compounds
331Assays
17Approved Drugs
5,966.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats BJ as ChEMBL target CHEMBL614358. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
BJ
CELL-LINE · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL614358
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether BJ still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelBJ
UniProt AccessionN/A

BJ

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as BJ.

Review nameBJ
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

17
Approved
1
Phase III
5
Phase II
1
Phase I
Assay Mix

Activity Type Distribution

IC50908.0
EC505,058.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL375269 9.7 IC50 0.2 Preclinical
CHEMBL2402277 8.89 EC50 1.3 Preclinical
CHEMBL388978 8.7 IC50 2.0 Preclinical
CHEMBL1775028 8.52 IC50 3.0 Preclinical
CHEMBL46286 8.31 EC50 4.88 Approved
CHEMBL1775023 8.3 IC50 5.0 Preclinical
CHEMBL1775022 8.15 IC50 7.0 Preclinical
CHEMBL274070 8.14 EC50 7.18 Clinical
CHEMBL513000 8.12 EC50 7.63 Preclinical
CHEMBL65 8.12 EC50 7.67 Preclinical
Distribution

pChEMBL Value Distribution

961
5.0
691
5.5
428
6.0
109
6.5
21
7.0
12
7.5
6
8.0
3
8.5
0
9.0
1
9.5
pChEMBL
Approved Drugs

Approved Drugs

OMACETAXINE MEPESUCCINATE
CHEMBL46286
Approved 2009
PITAVASTATIN CALCIUM
CHEMBL1237061
Approved 2009
VORINOSTAT
CHEMBL98
Approved 2006
CERIVASTATIN SODIUM
CHEMBL1200563
Approved 1997
TOPOTECAN HYDROCHLORIDE
CHEMBL1607
Approved 1996
RALTITREXED
CHEMBL225071
Approved 1996
IDARUBICIN HYDROCHLORIDE
CHEMBL1200976
Approved 1990
FLOXURIDINE
CHEMBL917
Approved 1970
Assay Landscape

Assay Landscape

331
Total Assays
1,184
Tested Compounds
4
Assay Types
Functional — 167 assays, 1,184 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 167 1,184 5.3
ADME — 142 assays, 381 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 142 381 5.1
Toxicity — 21 assays, 38 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 21 38 4.6
Unassigned — 1 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 1 0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine