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Target Snapshot

CHEMBL614372 Target Snapshot

C3H/3T3 · CELL-LINE · Mus musculus

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95Compounds
24Assays
2Approved Drugs
55.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats C3H/3T3 as ChEMBL target CHEMBL614372. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
C3H/3T3
CELL-LINE · Mus musculus
As of 2026-09-13
ChEMBL target ID
CHEMBL614372
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether C3H/3T3 still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameC3H/3T3
Target TypeCELL-LINE
OrganismMus musculus
ChEMBL ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelC3H/3T3
UniProt AccessionN/A

C3H/3T3

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as C3H/3T3.

Review nameC3H/3T3
OrganismMus musculus
Clinical Profile

Clinical Phase Distribution

2
Approved
Assay Mix

Activity Type Distribution

IC5010.0
EC5045.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL129 7.7 EC50 20.0 Approved
CHEMBL289329 6.52 EC50 300.0 Preclinical
CHEMBL41402 5.94 EC50 1140.0 Preclinical
CHEMBL42698 5.94 EC50 1140.0 Preclinical
CHEMBL40302 5.93 EC50 1180.0 Preclinical
CHEMBL41053 5.92 EC50 1210.0 Preclinical
CHEMBL40598 5.91 EC50 1240.0 Preclinical
CHEMBL295071 5.77 EC50 1700.0 Preclinical
CHEMBL128665 5.66 EC50 2200.0 Preclinical
CHEMBL2112391 5.55 EC50 2830.0 Preclinical
Distribution

pChEMBL Value Distribution

9
5.0
10
5.5
0
6.0
1
6.5
0
7.0
1
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

ZIDOVUDINE
CHEMBL129
Approved 1987
Properties Compare Identifier
Assay Landscape

Assay Landscape

24
Total Assays
30
Tested Compounds
1
Assay Types
Functional — 24 assays, 30 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 24 30 5.3

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine