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Target Snapshot

CHEMBL614388 Target Snapshot

UO-31 · CELL-LINE · Homo sapiens

42,630Compounds
890Assays
24Approved Drugs
205.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats UO-31 as ChEMBL target CHEMBL614388. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
UO-31
CELL-LINE · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL614388
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether UO-31 still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

Jump to Disease Context
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Evidence Card
Review-ready rationale with source-aware context

Open the one-page evidence card when you want the rationale, activity base, and attribution together.

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelUO-31
UniProt AccessionN/A

UO-31

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as UO-31.

Review nameUO-31
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

24
Approved
10
Phase III
9
Phase II
4
Phase I
Assay Mix

Activity Type Distribution

IC50205.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL888 9.25 IC50 0.5647 Approved
CHEMBL3545252 8.51 IC50 3.075 Approved
CHEMBL94657 8.51 IC50 3.116 Clinical
CHEMBL38957 8.39 IC50 4.05 Preclinical
CHEMBL18155 8.26 IC50 5.5 Preclinical
CHEMBL4535881 8.24 IC50 5.759 Preclinical
CHEMBL53463 8.13 IC50 7.453 Approved
CHEMBL44919 8.11 IC50 7.8 Preclinical
CHEMBL42819 8.1 IC50 8.0 Preclinical
CHEMBL4561572 8.06 IC50 8.604 Preclinical
Distribution

pChEMBL Value Distribution

24
5.0
41
5.5
12
6.0
7
6.5
10
7.0
4
7.5
9
8.0
2
8.5
1
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

MIDOSTAURIN
CHEMBL608533
Approved 2017
GEMCITABINE
CHEMBL888
Approved 1996
DOCETAXEL
CHEMBL3545252
Approved 1995
MITOMYCIN
CHEMBL105
Approved 1981
DOXORUBICIN
CHEMBL53463
Approved 1974
VINBLASTINE
CHEMBL159
Approved 1965
METHOTREXATE
CHEMBL34259
Approved 1953
Assay Landscape

Assay Landscape

890
Total Assays
175
Tested Compounds
2
Assay Types
Functional — 883 assays, 175 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 883 175 5.7
ADME — 7 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 7 0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine