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Target Snapshot

CHEMBL614391 Target Snapshot

WI-38 · CELL-LINE · Homo sapiens

Back to Search Search this target Browse approvals Evidence Card
2,272Compounds
457Assays
14Approved Drugs
2,036.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats WI-38 as ChEMBL target CHEMBL614391. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
WI-38
CELL-LINE · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL614391
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether WI-38 still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

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Evidence Card
Review-ready rationale with source-aware context

Open the one-page evidence card when you want the rationale, activity base, and attribution together.

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameWI-38
Target TypeCELL-LINE
OrganismHomo sapiens
ChEMBL ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelWI-38
UniProt AccessionN/A

WI-38

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as WI-38.

Review nameWI-38
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

14
Approved
1
Phase III
3
Phase II
2
Phase I
Assay Mix

Activity Type Distribution

IC501,892.0
EC50144.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL5274453 8.11 IC50 7.7 Preclinical
CHEMBL5270349 8.11 IC50 7.7 Preclinical
CHEMBL1796380 8.0 IC50 10.0 Preclinical
CHEMBL4776857 7.89 IC50 12.9 Preclinical
CHEMBL4781016 7.76 IC50 17.2 Preclinical
CHEMBL4791300 7.73 IC50 18.6 Preclinical
CHEMBL4785943 7.71 IC50 19.3 Preclinical
CHEMBL5189423 7.66 IC50 22.0 Preclinical
CHEMBL4758958 7.61 IC50 24.5 Preclinical
CHEMBL4797445 7.6 IC50 25.0 Preclinical
Distribution

pChEMBL Value Distribution

251
5.0
115
5.5
92
6.0
74
6.5
53
7.0
17
7.5
3
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

LAPATINIB
CHEMBL554
Approved 2007
Properties Compare Identifier
PACLITAXEL
CHEMBL428647
Approved 1992
Properties Compare Identifier
DOXORUBICIN
CHEMBL53463
Approved 1974
Properties Compare Identifier
DOXORUBICIN HYDROCHLORIDE
CHEMBL359744
Approved 1974
Properties Compare Identifier
FLUOROURACIL
CHEMBL185
Approved 1962
Properties Compare Identifier
NITROFURANTOIN
CHEMBL572
Approved 1953
Properties Compare Identifier
Assay Landscape

Assay Landscape

457
Total Assays
776
Tested Compounds
4
Assay Types
ADME — 200 assays, 776 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 200 776 5.2
Functional — 180 assays, 250 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 180 250 5.2
Toxicity — 76 assays, 198 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 76 198 5.2
Unassigned — 1 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 1 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine