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Target Snapshot

CHEMBL614392 Target Snapshot

HaCaT · CELL-LINE · Homo sapiens

Back to Search Search this target Browse approvals Evidence Card
2,362Compounds
763Assays
17Approved Drugs
1,535.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats HaCaT as ChEMBL target CHEMBL614392. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
HaCaT
CELL-LINE · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL614392
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether HaCaT still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

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Need a meeting-ready explanation of why this target matters?
Evidence Card
Review-ready rationale with source-aware context

Open the one-page evidence card when you want the rationale, activity base, and attribution together.

Open Review-ready Card
Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameHaCaT
Target TypeCELL-LINE
OrganismHomo sapiens
ChEMBL ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelHaCaT
UniProt AccessionN/A

HaCaT

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as HaCaT.

Review nameHaCaT
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

17
Approved
6
Phase III
7
Phase II
Assay Mix

Activity Type Distribution

IC501,497.0
EC5038.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL4794117 10.52 IC50 0.03 Preclinical
CHEMBL4800456 9.52 IC50 0.3 Preclinical
CHEMBL107 9.52 IC50 0.3 Approved
CHEMBL1221966 9.38 IC50 0.42 Preclinical
CHEMBL4753994 9.3 IC50 0.5 Preclinical
CHEMBL4797732 9.22 IC50 0.6 Preclinical
CHEMBL4743585 9.22 IC50 0.6 Preclinical
CHEMBL3126408 9.05 IC50 0.9 Preclinical
CHEMBL67 9.0 IC50 1.0 Preclinical
CHEMBL428647 8.7 IC50 2.0 Approved
Distribution

pChEMBL Value Distribution

151
5.0
161
5.5
136
6.0
50
6.5
30
7.0
26
7.5
11
8.0
8
8.5
6
9.0
2
9.5
pChEMBL
Approved Drugs

Approved Drugs

PACLITAXEL
CHEMBL428647
Approved 1992
Properties Compare Identifier
ETOPOSIDE
CHEMBL44657
Approved 1983
Properties Compare Identifier
DOXORUBICIN
CHEMBL53463
Approved 1974
Properties Compare Identifier
VINCRISTINE
CHEMBL90555
Approved 1963
Properties Compare Identifier
FLUOROURACIL
CHEMBL185
Approved 1962
Properties Compare Identifier
COLCHICINE
CHEMBL107
Approved 1961
Properties Compare Identifier
Assay Landscape

Assay Landscape

768
Total Assays
528
Tested Compounds
4
Assay Types
Functional — 369 assays, 528 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 369 528 5.7
ADME — 302 assays, 321 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 302 321 5.2
Toxicity — 95 assays, 78 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 95 78 5.5
Unassigned — 2 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 2 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine