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Target Snapshot

CHEMBL614454 Target Snapshot

SNU-398 · CELL-LINE · Homo sapiens

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364Compounds
65Assays
9Approved Drugs
368.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats SNU-398 as ChEMBL target CHEMBL614454. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
SNU-398
CELL-LINE · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL614454
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether SNU-398 still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameSNU-398
Target TypeCELL-LINE
OrganismHomo sapiens
ChEMBL ↗

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelSNU-398
UniProt AccessionN/A

SNU-398

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as SNU-398.

Review nameSNU-398
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

9
Approved
2
Phase III
1
Phase II
Assay Mix

Activity Type Distribution

IC5059.0
EC50309.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL428647 9.22 IC50 0.6 Approved
CHEMBL428240 9.0 EC50 1.0 Preclinical
CHEMBL522491 9.0 EC50 1.0 Preclinical
CHEMBL1336 9.0 IC50 1.0 Approved
CHEMBL399124 8.7 EC50 2.0 Preclinical
CHEMBL254236 8.7 EC50 2.0 Preclinical
CHEMBL398341 8.7 EC50 2.0 Preclinical
CHEMBL474387 8.7 EC50 2.0 Preclinical
CHEMBL492399 8.7 EC50 2.0 Clinical
CHEMBL492725 8.7 EC50 2.0 Preclinical
Distribution

pChEMBL Value Distribution

34
5.0
38
5.5
38
6.0
41
6.5
25
7.0
29
7.5
18
8.0
16
8.5
4
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

VORINOSTAT
CHEMBL98
Approved 2006
Properties Compare Identifier
SORAFENIB
CHEMBL1336
Approved 2005
Properties Compare Identifier
DOCETAXEL
CHEMBL3545252
Approved 1995
Properties Compare Identifier
PACLITAXEL
CHEMBL428647
Approved 1992
Properties Compare Identifier
VINBLASTINE
CHEMBL159
Approved 1965
Properties Compare Identifier
VINCRISTINE
CHEMBL90555
Approved 1963
Properties Compare Identifier
COLCHICINE
CHEMBL107
Approved 1961
Properties Compare Identifier
Assay Landscape

Assay Landscape

65
Total Assays
229
Tested Compounds
2
Assay Types
Functional — 64 assays, 229 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 64 229 6.7
ADME — 1 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 1 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine