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Target Snapshot

CHEMBL614457 Target Snapshot

CHRC5 cell line · CELL-LINE · Cricetulus griseus

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80Compounds
7Assays
2Approved Drugs
78.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats CHRC5 cell line as ChEMBL target CHEMBL614457. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
CHRC5 cell line
CELL-LINE · Cricetulus griseus
As of 2026-09-13
ChEMBL target ID
CHEMBL614457
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether CHRC5 cell line still has a stable protein naming contract across sources.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameCHRC5 cell line
Target TypeCELL-LINE
OrganismCricetulus griseus
ChEMBL ↗

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelCHRC5 cell line
UniProt AccessionN/A

CHRC5 cell line

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as CHRC5 cell line.

Review nameCHRC5 cell line
OrganismCricetulus griseus
Clinical Profile

Clinical Phase Distribution

2
Approved
1
Phase II
Assay Mix

Activity Type Distribution

EC5078.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL78571 7.75 EC50 18.0 Preclinical
CHEMBL77905 7.68 EC50 21.0 Preclinical
CHEMBL309650 7.68 EC50 21.0 Preclinical
CHEMBL80012 7.68 EC50 21.0 Preclinical
CHEMBL80117 7.68 EC50 20.7 Preclinical
CHEMBL396298 7.68 EC50 21.0 Clinical
CHEMBL81789 7.66 EC50 22.0 Preclinical
CHEMBL309747 7.57 EC50 27.0 Preclinical
CHEMBL81815 7.52 EC50 30.0 Preclinical
CHEMBL81344 7.52 EC50 30.0 Preclinical
Distribution

pChEMBL Value Distribution

0
5.0
5
5.5
15
6.0
19
6.5
25
7.0
10
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

7
Total Assays
66
Tested Compounds
1
Assay Types
Functional — 7 assays, 66 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 7 66 6.9

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine