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Target Snapshot

CHEMBL614466 Target Snapshot

Colon 26 · CELL-LINE · Mus musculus

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215Compounds
237Assays
3Approved Drugs
149.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Colon 26 as ChEMBL target CHEMBL614466. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Colon 26
CELL-LINE · Mus musculus
As of 2026-09-14
ChEMBL target ID
CHEMBL614466
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Colon 26 still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameColon 26
Target TypeCELL-LINE
OrganismMus musculus
ChEMBL ↗

Next Actions

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelColon 26
UniProt AccessionN/A

Colon 26

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Colon 26.

Review nameColon 26
OrganismMus musculus
Clinical Profile

Clinical Phase Distribution

3
Approved
2
Phase III
1
Phase II
Assay Mix

Activity Type Distribution

IC50102.0
EC5047.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL330407 8.55 IC50 2.8 Preclinical
CHEMBL542922 8.55 IC50 2.8 Preclinical
CHEMBL41056 8.52 IC50 3.0 Preclinical
CHEMBL296373 8.32 IC50 4.8 Clinical
CHEMBL103582 8.23 IC50 5.9 Preclinical
CHEMBL324397 8.14 IC50 7.2 Preclinical
CHEMBL42159 8.1 IC50 8.0 Preclinical
CHEMBL102838 8.09 IC50 8.1 Preclinical
CHEMBL108621 8.08 IC50 8.4 Preclinical
CHEMBL67 8.06 IC50 8.7 Preclinical
Distribution

pChEMBL Value Distribution

12
5.0
13
5.5
11
6.0
23
6.5
17
7.0
12
7.5
11
8.0
4
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

265
Total Assays
96
Tested Compounds
3
Assay Types
Functional — 242 assays, 96 compounds
BAO Format Assays Compounds Avg pChEMBL
organism-based format 167 0 —
cell-based format 75 96 6.6
ADME — 13 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 13 0 —
Toxicity — 10 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 10 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine