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Target Snapshot

CHEMBL614469 Target Snapshot

Colon cell · CELL-LINE · Homo sapiens

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23Compounds
7Assays
0Approved Drugs
20.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Colon cell as ChEMBL target CHEMBL614469. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Colon cell
CELL-LINE · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL614469
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Colon cell still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

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Evidence Card
Review-ready rationale with source-aware context

Open the one-page evidence card when you want the rationale, activity base, and attribution together.

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameColon cell
Target TypeCELL-LINE
OrganismHomo sapiens
ChEMBL ↗

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelColon cell
UniProt AccessionN/A

Colon cell

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Colon cell.

Review nameColon cell
OrganismHomo sapiens
Assay Mix

Activity Type Distribution

IC5020.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL41728 5.36 IC50 4365.16 Preclinical
CHEMBL43690 4.52 IC50 30199.52 Preclinical
CHEMBL285295 4.45 IC50 35481.34 Preclinical
CHEMBL290894 4.38 IC50 41686.94 Preclinical
CHEMBL40267 4.34 IC50 45708.82 Preclinical
CHEMBL282939 4.33 IC50 46773.51 Preclinical
CHEMBL39346 4.27 IC50 53703.18 Preclinical
CHEMBL290601 4.17 IC50 67608.3 Preclinical
CHEMBL290939 4.13 IC50 74131.02 Preclinical
CHEMBL287884 4.06 IC50 87096.36 Preclinical
Distribution

pChEMBL Value Distribution

1
5.0
0
5.5
0
6.0
0
6.5
0
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

7
Total Assays
13
Tested Compounds
1
Assay Types
Functional — 7 assays, 13 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 7 13 4.3

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine